Skip to main content
Journal cover image

Correlation of hippocampal neuronal density and FDG-PET in mesial temporal lobe epilepsy.

Publication ,  Journal Article
Foldvary, N; Lee, N; Hanson, MW; Coleman, RE; Hulette, CM; Friedman, AH; Bej, MD; Radtke, RA
Published in: Epilepsia
January 1999

PURPOSE: Interictal [18F]fluorodeoxyglucose (FDG) positron emission tomography (PET) reveals regional hypometabolism in 60-80% of patients with mesial temporal lobe epilepsy (MTLE). The extent of hypometabolism generally extends beyond the epileptogenic zone. The pathophysiology underlying this widespread change is unknown. This study evaluated the relation between hippocampal neuronal loss and hypometabolism in patients with MTLE. METHODS: Forty-three patients with MTLE after anterior temporal lobectomy were included. Pathology demonstrated mesial temporal sclerosis (n = 41) or endfolium sclerosis (n = 2). Interictal FDG-PET scans were graded by visual analysis on a scale ranging from normal (grade 1) to severe (grade 5) hypometabolism. Neuronal counting was performed in the subiculum, hippocampal subfields, and dentate granular cell layer (DG). Neuronal density of patients was compared with that of seven autopsy controls. Data were compared by using Student's t tests and Kruskal-Wallis one-way analysis of variance (ANOVA). RESULTS: Significant neuronal loss in CA1 through CA4 and DG was found in patients compared with controls. Neuronal density in the subiculum, CA1, CA4, and DG did not correlate with severity of hypometabolism. However, patients with abnormal FDG-PET had higher neuronal density in CA2 and CA3 versus patients with normal studies. CONCLUSIONS: This study supports a previous observation that degree of FDG-PET hypometabolism does not parallel severity of hippocampal neuronal loss in MTLE.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Epilepsia

DOI

ISSN

0013-9580

Publication Date

January 1999

Volume

40

Issue

1

Start / End Page

26 / 29

Location

United States

Related Subject Headings

  • Tomography, Emission-Computed
  • Pyramidal Cells
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Humans
  • Hippocampus
  • Glucose
  • Fluorodeoxyglucose F18
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Foldvary, N., Lee, N., Hanson, M. W., Coleman, R. E., Hulette, C. M., Friedman, A. H., … Radtke, R. A. (1999). Correlation of hippocampal neuronal density and FDG-PET in mesial temporal lobe epilepsy. Epilepsia, 40(1), 26–29. https://doi.org/10.1111/j.1528-1157.1999.tb01984.x
Foldvary, N., N. Lee, M. W. Hanson, R. E. Coleman, C. M. Hulette, A. H. Friedman, M. D. Bej, and R. A. Radtke. “Correlation of hippocampal neuronal density and FDG-PET in mesial temporal lobe epilepsy.Epilepsia 40, no. 1 (January 1999): 26–29. https://doi.org/10.1111/j.1528-1157.1999.tb01984.x.
Foldvary N, Lee N, Hanson MW, Coleman RE, Hulette CM, Friedman AH, et al. Correlation of hippocampal neuronal density and FDG-PET in mesial temporal lobe epilepsy. Epilepsia. 1999 Jan;40(1):26–9.
Foldvary, N., et al. “Correlation of hippocampal neuronal density and FDG-PET in mesial temporal lobe epilepsy.Epilepsia, vol. 40, no. 1, Jan. 1999, pp. 26–29. Pubmed, doi:10.1111/j.1528-1157.1999.tb01984.x.
Foldvary N, Lee N, Hanson MW, Coleman RE, Hulette CM, Friedman AH, Bej MD, Radtke RA. Correlation of hippocampal neuronal density and FDG-PET in mesial temporal lobe epilepsy. Epilepsia. 1999 Jan;40(1):26–29.
Journal cover image

Published In

Epilepsia

DOI

ISSN

0013-9580

Publication Date

January 1999

Volume

40

Issue

1

Start / End Page

26 / 29

Location

United States

Related Subject Headings

  • Tomography, Emission-Computed
  • Pyramidal Cells
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Humans
  • Hippocampus
  • Glucose
  • Fluorodeoxyglucose F18
  • Female