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Prevalence of antibodies to rotavirus in different age-groups of infants in Bochum, West Germany.

Publication ,  Journal Article
Brüssow, H; Werchau, H; Liedtke, W; Lerner, L; Mietens, C; Sidoti, J; Sotek, J
Published in: J Infect Dis
May 1988

We studied the prevalence of antibody to rotavirus in 386 serum samples obtained from different age-groups of infants in Bochum, West Germany. Cord sera mirrored the IgG titer and serotype specificity of the corresponding maternal sera. IgG antibody prevalence decreased with age, reached a minimum between four and 12 months, and increased thereafter. IgM antibodies appeared first in the eight- to 12-month age-group, and IgM prevalence remained high thereafter. The serum level of IgA was low in all age-groups. Significant prevalence increases with increasing age were observed for neutralizing antibodies to rotavirus serotypes 1 and 3. Antibodies to serotype 4 had not reached adult level at 2.5 y of age. Prevalence of antibodies to serotype 2 was low in all age-groups. The percentage of monospecific sera neutralizing only one serotype was high in young infants eight to 12 months of age and decreased significantly with increasing age.

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Published In

J Infect Dis

DOI

ISSN

0022-1899

Publication Date

May 1988

Volume

157

Issue

5

Start / End Page

1014 / 1022

Location

United States

Related Subject Headings

  • Serotyping
  • Rotavirus
  • Neutralization Tests
  • Microbiology
  • Infant, Newborn
  • Infant
  • Immunoglobulin M
  • Immunoglobulin G
  • Immunoglobulin A
  • Immunity, Maternally-Acquired
 

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Brüssow, H., Werchau, H., Liedtke, W., Lerner, L., Mietens, C., Sidoti, J., & Sotek, J. (1988). Prevalence of antibodies to rotavirus in different age-groups of infants in Bochum, West Germany. J Infect Dis, 157(5), 1014–1022. https://doi.org/10.1093/infdis/157.5.1014
Brüssow, H., H. Werchau, W. Liedtke, L. Lerner, C. Mietens, J. Sidoti, and J. Sotek. “Prevalence of antibodies to rotavirus in different age-groups of infants in Bochum, West Germany.J Infect Dis 157, no. 5 (May 1988): 1014–22. https://doi.org/10.1093/infdis/157.5.1014.
Brüssow H, Werchau H, Liedtke W, Lerner L, Mietens C, Sidoti J, et al. Prevalence of antibodies to rotavirus in different age-groups of infants in Bochum, West Germany. J Infect Dis. 1988 May;157(5):1014–22.
Brüssow, H., et al. “Prevalence of antibodies to rotavirus in different age-groups of infants in Bochum, West Germany.J Infect Dis, vol. 157, no. 5, May 1988, pp. 1014–22. Pubmed, doi:10.1093/infdis/157.5.1014.
Brüssow H, Werchau H, Liedtke W, Lerner L, Mietens C, Sidoti J, Sotek J. Prevalence of antibodies to rotavirus in different age-groups of infants in Bochum, West Germany. J Infect Dis. 1988 May;157(5):1014–1022.
Journal cover image

Published In

J Infect Dis

DOI

ISSN

0022-1899

Publication Date

May 1988

Volume

157

Issue

5

Start / End Page

1014 / 1022

Location

United States

Related Subject Headings

  • Serotyping
  • Rotavirus
  • Neutralization Tests
  • Microbiology
  • Infant, Newborn
  • Infant
  • Immunoglobulin M
  • Immunoglobulin G
  • Immunoglobulin A
  • Immunity, Maternally-Acquired