Scholars@Duke publication: Seroconversion patterns to four human rotavirus serotypes in hospitalized infants with acute rotavirus gastroenteritis.

Seroconversion patterns to four human rotavirus serotypes in hospitalized infants with acute rotavirus gastroenteritis.

Publication , Journal Article

Brüssow, H; Werchau, H; Lerner, L; Mietens, C; Liedtke, W; Sidoti, J; Sotek, J

Published in: J Infect Dis

September 1988

We studied rotavirus-specific antibodies in paired sera from 71 hospitalized infants with acute rotavirus gastroenteritis. Most of the infants were less than six months old. Infants with serological evidence of a secondary rotavirus infection were excluded. With an enzyme-linked immunosorbent assay, 46% of the 71 infants studied showed specific IgM in convalescent sera. Titers of specific IgG and IgA increased in 7% and 2% of the infants, respectively. The presence of specific IgM correlated positively with age and severity of clinical symptoms. With a neutralization test, 59% of the infants showed a seroconversion: 20% to a single serotype (7% to serotype 1, 7% to serotype 3, and 6% to serotype 4), 21% seroconverted to two serotypes (nearly exclusively to serotypes 1 and 3), and 18% seroconverted to three serotypes (exclusively to serotypes 1, 3, and 4). No infant seroconverted to serotype 2 or to the heterologous (bovine) serotype 6.

Duke Scholars

Author Wolfgang Bernhard Liedtke Neurology, Headache and Pain

Published In

J Infect Dis

DOI

10.1093/infdis/158.3.588

ISSN

0022-1899

Publication Date

September 1988

Volume

158

Issue

Start / End Page

588 / 595

Location

United States

Related Subject Headings

Serotyping
Rotavirus Infections
Rotavirus
Neutralization Tests
Microbiology
Male
Infant
Immunoglobulin M
Immunoglobulin G
Immunoglobulin A

Citation

APA

Chicago

ICMJE

MLA

NLM

Brüssow, H., Werchau, H., Lerner, L., Mietens, C., Liedtke, W., Sidoti, J., & Sotek, J. (1988). Seroconversion patterns to four human rotavirus serotypes in hospitalized infants with acute rotavirus gastroenteritis. J Infect Dis, 158(3), 588–595. https://doi.org/10.1093/infdis/158.3.588

Brüssow, H., H. Werchau, L. Lerner, C. Mietens, W. Liedtke, J. Sidoti, and J. Sotek. “Seroconversion patterns to four human rotavirus serotypes in hospitalized infants with acute rotavirus gastroenteritis.” J Infect Dis 158, no. 3 (September 1988): 588–95. https://doi.org/10.1093/infdis/158.3.588.

Brüssow H, Werchau H, Lerner L, Mietens C, Liedtke W, Sidoti J, et al. Seroconversion patterns to four human rotavirus serotypes in hospitalized infants with acute rotavirus gastroenteritis. J Infect Dis. 1988 Sep;158(3):588–95.

Brüssow, H., et al. “Seroconversion patterns to four human rotavirus serotypes in hospitalized infants with acute rotavirus gastroenteritis.” J Infect Dis, vol. 158, no. 3, Sept. 1988, pp. 588–95. Pubmed, doi:10.1093/infdis/158.3.588.

Brüssow H, Werchau H, Lerner L, Mietens C, Liedtke W, Sidoti J, Sotek J. Seroconversion patterns to four human rotavirus serotypes in hospitalized infants with acute rotavirus gastroenteritis. J Infect Dis. 1988 Sep;158(3):588–595.