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Very-late-onset adrenoleukodystrophy: possible precipitation of demyelination by cerebral contusion.

Publication ,  Journal Article
Weller, M; Liedtke, W; Petersen, D; Opitz, H; Poremba, M
Published in: Neurology
February 1992

We report the clinical history, neuroradiology, and autopsy findings in a patient with very late onset, at age 57, of adrenoleukodystrophy (ALD) presenting with dementia, hemianopia, and gait apraxia. Open brain biopsy, elevated plasma very-long-chain fatty acids, and autopsy confirmed the diagnosis of ALD. Demyelinative lesions were most extensive at the site of a recent cerebral contusion. CNS trauma may have precipitated or accelerated demyelination in this patient carrying the ALD gene.

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Published In

Neurology

DOI

ISSN

0028-3878

Publication Date

February 1992

Volume

42

Issue

2

Start / End Page

367 / 370

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Fatty Acids
  • Demyelinating Diseases
  • Brain Concussion
  • Age Factors
 

Citation

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ICMJE
MLA
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Weller, M., Liedtke, W., Petersen, D., Opitz, H., & Poremba, M. (1992). Very-late-onset adrenoleukodystrophy: possible precipitation of demyelination by cerebral contusion. Neurology, 42(2), 367–370. https://doi.org/10.1212/wnl.42.2.367
Weller, M., W. Liedtke, D. Petersen, H. Opitz, and M. Poremba. “Very-late-onset adrenoleukodystrophy: possible precipitation of demyelination by cerebral contusion.Neurology 42, no. 2 (February 1992): 367–70. https://doi.org/10.1212/wnl.42.2.367.
Weller M, Liedtke W, Petersen D, Opitz H, Poremba M. Very-late-onset adrenoleukodystrophy: possible precipitation of demyelination by cerebral contusion. Neurology. 1992 Feb;42(2):367–70.
Weller, M., et al. “Very-late-onset adrenoleukodystrophy: possible precipitation of demyelination by cerebral contusion.Neurology, vol. 42, no. 2, Feb. 1992, pp. 367–70. Pubmed, doi:10.1212/wnl.42.2.367.
Weller M, Liedtke W, Petersen D, Opitz H, Poremba M. Very-late-onset adrenoleukodystrophy: possible precipitation of demyelination by cerebral contusion. Neurology. 1992 Feb;42(2):367–370.

Published In

Neurology

DOI

ISSN

0028-3878

Publication Date

February 1992

Volume

42

Issue

2

Start / End Page

367 / 370

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Fatty Acids
  • Demyelinating Diseases
  • Brain Concussion
  • Age Factors