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Transient receptor potential vanilloid channels functioning in transduction of osmotic stimuli.

Publication ,  Journal Article
Liedtke, W
Published in: J Endocrinol
December 2006

In signal transduction of metazoan cells, ion channels of the family of transient receptor potential (TRP) have been identified to respond to diverse external and internal stimuli, amongst them osmotic stimuli. This review will highlight findings on the TRPV subfamily, both vertebrate and invertebrate members. Out of the six mammalian TRP vanilloid (TRPV) channels, TRPV1, TRPV2, and TRPV4 were demonstrated to function in transduction of osmotic stimuli. TRPV channels have been found to function in cellular as well as systemic osmotic homeostasis in vertebrates. Invertebrate TRPV channels, five in Caenorhabditis elegans and two in Drosophila, have been shown to play a role in mechanosensation, such as hearing and proprioception in Drosophila and nose touch in C. elegans, and in the response to osmotic stimuli in C. elegans. In a striking example of evolutionary conservation of function, mammalian TRPV4 has been found to rescue osmo- and mechanosensory deficits of the TRPV mutant strain osm-9 in C. elegans, despite not more than 26% orthology of the respective proteins.

Duke Scholars

Published In

J Endocrinol

DOI

ISSN

0022-0795

Publication Date

December 2006

Volume

191

Issue

3

Start / End Page

515 / 523

Location

England

Related Subject Headings

  • TRPV Cation Channels
  • Signal Transduction
  • Pain
  • Osmosis
  • Mice, Knockout
  • Mice
  • Mechanoreceptors
  • Endocrinology & Metabolism
  • Cell Physiological Phenomena
  • Caenorhabditis elegans
 

Citation

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MLA
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Liedtke, W. (2006). Transient receptor potential vanilloid channels functioning in transduction of osmotic stimuli. J Endocrinol, 191(3), 515–523. https://doi.org/10.1677/joe.1.07000
Liedtke, Wolfgang. “Transient receptor potential vanilloid channels functioning in transduction of osmotic stimuli.J Endocrinol 191, no. 3 (December 2006): 515–23. https://doi.org/10.1677/joe.1.07000.
Liedtke, Wolfgang. “Transient receptor potential vanilloid channels functioning in transduction of osmotic stimuli.J Endocrinol, vol. 191, no. 3, Dec. 2006, pp. 515–23. Pubmed, doi:10.1677/joe.1.07000.
Journal cover image

Published In

J Endocrinol

DOI

ISSN

0022-0795

Publication Date

December 2006

Volume

191

Issue

3

Start / End Page

515 / 523

Location

England

Related Subject Headings

  • TRPV Cation Channels
  • Signal Transduction
  • Pain
  • Osmosis
  • Mice, Knockout
  • Mice
  • Mechanoreceptors
  • Endocrinology & Metabolism
  • Cell Physiological Phenomena
  • Caenorhabditis elegans