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Exposure-response analysis of risk of respiratory disease associated with occupational exposure to chrysotile asbestos.

Publication ,  Journal Article
Stayner, L; Smith, R; Bailer, J; Gilbert, S; Steenland, K; Dement, J; Brown, D; Lemen, R
Published in: Occup Environ Med
September 1997

OBJECTIVES: To evaluate alternative models and estimate risk of mortality from lung cancer and asbestosis after occupational exposure to chrysotile asbestos. METHODS: Data were used from a recent update of a cohort mortality study of workers in a South Carolina textile factory. Alternative exposure-response models were evaluated with Poisson regression. A model designed to evaluate evidence of a threshold response was also fitted. Lifetime risks of lung cancer and asbestosis were estimated with an actuarial approach that accounts for competing causes of death. RESULTS: A highly significant exposure-response relation was found for both lung cancer and asbestosis. The exposure-response relation for lung cancer seemed to be linear on a multiplicative scale, which is consistent with previous analyses of lung cancer and exposure to asbestos. In contrast, the exposure-response relation for asbestosis seemed to be nonlinear on a multiplicative scale in this analysis. There was no significant evidence for a threshold in models of either the lung cancer or asbestosis. The excess lifetime risk for white men exposed for 45 years at the recently revised OSHA standard of 0.1 fibre/ml was predicted to be about 5/1000 for lung cancer, and 2/1000 for asbestosis. CONCLUSIONS: This study confirms the findings from previous investigations of a strong exposure-response relation between exposure to chrysotile asbestos and mortality from lung cancer, and asbestosis. The risk estimates for lung cancer derived from this analysis are higher than those derived from other populations exposed to chrysotile asbestos. Possible reasons for this discrepancy are discussed.

Duke Scholars

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Published In

Occup Environ Med

DOI

ISSN

1351-0711

Publication Date

September 1997

Volume

54

Issue

9

Start / End Page

646 / 652

Location

England

Related Subject Headings

  • South Carolina
  • Risk Factors
  • Respiratory Tract Neoplasms
  • Regression Analysis
  • Pneumoconiosis
  • Occupational Exposure
  • Models, Biological
  • Middle Aged
  • Male
  • Humans
 

Citation

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Stayner, L., Smith, R., Bailer, J., Gilbert, S., Steenland, K., Dement, J., … Lemen, R. (1997). Exposure-response analysis of risk of respiratory disease associated with occupational exposure to chrysotile asbestos. Occup Environ Med, 54(9), 646–652. https://doi.org/10.1136/oem.54.9.646
Stayner, L., R. Smith, J. Bailer, S. Gilbert, K. Steenland, J. Dement, D. Brown, and R. Lemen. “Exposure-response analysis of risk of respiratory disease associated with occupational exposure to chrysotile asbestos.Occup Environ Med 54, no. 9 (September 1997): 646–52. https://doi.org/10.1136/oem.54.9.646.
Stayner L, Smith R, Bailer J, Gilbert S, Steenland K, Dement J, et al. Exposure-response analysis of risk of respiratory disease associated with occupational exposure to chrysotile asbestos. Occup Environ Med. 1997 Sep;54(9):646–52.
Stayner, L., et al. “Exposure-response analysis of risk of respiratory disease associated with occupational exposure to chrysotile asbestos.Occup Environ Med, vol. 54, no. 9, Sept. 1997, pp. 646–52. Pubmed, doi:10.1136/oem.54.9.646.
Stayner L, Smith R, Bailer J, Gilbert S, Steenland K, Dement J, Brown D, Lemen R. Exposure-response analysis of risk of respiratory disease associated with occupational exposure to chrysotile asbestos. Occup Environ Med. 1997 Sep;54(9):646–652.

Published In

Occup Environ Med

DOI

ISSN

1351-0711

Publication Date

September 1997

Volume

54

Issue

9

Start / End Page

646 / 652

Location

England

Related Subject Headings

  • South Carolina
  • Risk Factors
  • Respiratory Tract Neoplasms
  • Regression Analysis
  • Pneumoconiosis
  • Occupational Exposure
  • Models, Biological
  • Middle Aged
  • Male
  • Humans