Growth factors modulate gonadotropin receptor induction in granulosa cell cultures.
Publication
, Journal Article
Mondschein, JS; Schomberg, DW
Published in: Science
March 13, 1981
Epidermal growth factor and fibroblast growth factor inhibited follicle-stimulating hormone-dependent induction of luteinizing hormone receptor in cultured ovarian granulosa cells of the rat. In contrast, platelet-derived growth factor potentiated the induction of luteinizing hormone receptor by follicle-stimulating hormone. These results indicate that growth factors, well known for their effects on mitosis and DNA synthesis in cultured mammalian cells, are also able to modulate hormone-dependent differentiation in an endocrine target cell.
Duke Scholars
Published In
Science
DOI
ISSN
0036-8075
Publication Date
March 13, 1981
Volume
211
Issue
4487
Start / End Page
1179 / 1180
Location
United States
Related Subject Headings
- Receptors, LHRH
- Receptors, Cell Surface
- Rats
- Peptides
- Luteinizing Hormone
- Growth Substances
- Granulosa Cells
- General Science & Technology
- Follicle Stimulating Hormone
- Fibroblasts
Citation
APA
Chicago
ICMJE
MLA
NLM
Mondschein, J. S., & Schomberg, D. W. (1981). Growth factors modulate gonadotropin receptor induction in granulosa cell cultures. Science, 211(4487), 1179–1180. https://doi.org/10.1126/science.6258228
Mondschein, J. S., and D. W. Schomberg. “Growth factors modulate gonadotropin receptor induction in granulosa cell cultures.” Science 211, no. 4487 (March 13, 1981): 1179–80. https://doi.org/10.1126/science.6258228.
Mondschein JS, Schomberg DW. Growth factors modulate gonadotropin receptor induction in granulosa cell cultures. Science. 1981 Mar 13;211(4487):1179–80.
Mondschein, J. S., and D. W. Schomberg. “Growth factors modulate gonadotropin receptor induction in granulosa cell cultures.” Science, vol. 211, no. 4487, Mar. 1981, pp. 1179–80. Pubmed, doi:10.1126/science.6258228.
Mondschein JS, Schomberg DW. Growth factors modulate gonadotropin receptor induction in granulosa cell cultures. Science. 1981 Mar 13;211(4487):1179–1180.
Published In
Science
DOI
ISSN
0036-8075
Publication Date
March 13, 1981
Volume
211
Issue
4487
Start / End Page
1179 / 1180
Location
United States
Related Subject Headings
- Receptors, LHRH
- Receptors, Cell Surface
- Rats
- Peptides
- Luteinizing Hormone
- Growth Substances
- Granulosa Cells
- General Science & Technology
- Follicle Stimulating Hormone
- Fibroblasts