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Kinetic modeling of tumor growth and dissemination in the craniospinal axis: implications for craniospinal irradiation.

Publication ,  Journal Article
Meyer, JJ; Marks, LB; Halperin, EC; Kirkpatrick, JP
Published in: Radiat Oncol
December 22, 2006

BACKGROUND: Medulloblastoma and other types of tumors that gain access to the cerebrospinal fluid can spread throughout the craniospinal axis. The purpose of this study was to devise a simple multi-compartment kinetic model using established tumor cell growth and treatment sensitivity parameters to model the complications of this spread as well as the impact of treatment with craniospinal radiotherapy. METHODS: A two-compartment mathematical model was constructed. Rate constants were derived from previously published work and the model used to predict outcomes for various clinical scenarios. RESULTS: The model is simple and with the use of known and estimated clinical parameters is consistent with known clinical outcomes. Treatment outcomes are critically dependent upon the duration of the treatment break and the radiosensitivity of the tumor. Cross-plot analyses serve as an estimate of likelihood of cure as a function of these and other factors. CONCLUSION: The model accurately describes known clinical outcomes for patients with medulloblastoma. It can help guide treatment decisions for radiation oncologists treating patients with this disease. Incorporation of other treatment modalities, such as chemotherapy, that enhance radiation sensitivity and/or reduce tumor burden, are predicted to significantly increase the probability of cure.

Duke Scholars

Published In

Radiat Oncol

DOI

ISSN

1748-717X

Publication Date

December 22, 2006

Volume

1

Start / End Page

48

Location

England

Related Subject Headings

  • Risk
  • Radiation Oncology
  • Oncology & Carcinogenesis
  • Models, Theoretical
  • Models, Statistical
  • Medulloblastoma
  • Kinetics
  • Humans
  • Cranial Irradiation
  • Cerebrospinal Fluid
 

Citation

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Meyer, J. J., Marks, L. B., Halperin, E. C., & Kirkpatrick, J. P. (2006). Kinetic modeling of tumor growth and dissemination in the craniospinal axis: implications for craniospinal irradiation. Radiat Oncol, 1, 48. https://doi.org/10.1186/1748-717X-1-48
Meyer, Jeffrey J., Lawrence B. Marks, Edward C. Halperin, and John P. Kirkpatrick. “Kinetic modeling of tumor growth and dissemination in the craniospinal axis: implications for craniospinal irradiation.Radiat Oncol 1 (December 22, 2006): 48. https://doi.org/10.1186/1748-717X-1-48.
Meyer JJ, Marks LB, Halperin EC, Kirkpatrick JP. Kinetic modeling of tumor growth and dissemination in the craniospinal axis: implications for craniospinal irradiation. Radiat Oncol. 2006 Dec 22;1:48.
Meyer, Jeffrey J., et al. “Kinetic modeling of tumor growth and dissemination in the craniospinal axis: implications for craniospinal irradiation.Radiat Oncol, vol. 1, Dec. 2006, p. 48. Pubmed, doi:10.1186/1748-717X-1-48.
Meyer JJ, Marks LB, Halperin EC, Kirkpatrick JP. Kinetic modeling of tumor growth and dissemination in the craniospinal axis: implications for craniospinal irradiation. Radiat Oncol. 2006 Dec 22;1:48.
Journal cover image

Published In

Radiat Oncol

DOI

ISSN

1748-717X

Publication Date

December 22, 2006

Volume

1

Start / End Page

48

Location

England

Related Subject Headings

  • Risk
  • Radiation Oncology
  • Oncology & Carcinogenesis
  • Models, Theoretical
  • Models, Statistical
  • Medulloblastoma
  • Kinetics
  • Humans
  • Cranial Irradiation
  • Cerebrospinal Fluid