Skip to main content

High level expression of CD43 inhibits T cell receptor/CD3-mediated apoptosis.

Publication ,  Journal Article
He, YW; Bevan, MJ
Published in: J Exp Med
December 20, 1999

In a screen designed to identify genes that regulate T cell receptor (TCR)/CD3-mediated apoptosis, we found that high level expression of CD43 protected T cell hybridomas from activation-induced cell death. The protection appears to result from its capacity to block Fas-mediated death signals rather than from inhibition of the upregulation of Fas and/or Fas ligand after T cell stimulation. We found that peripheral CD4(+) T cells can be divided into two subsets based on the level of CD43 surface expression. The CD4(+)CD43(low) subset exhibits a naive T cell phenotype, being CD62L(high)CD45RB(high)CD44(low), whereas CD4(+)CD43(high) cells exhibit a memory phenotype, being CD62L(low)CD45RB(low)CD44(high). Recent studies have demonstrated that engagement of TCR and Fas induces naive CD4(+) T cells to undergo apoptosis, and the same treatment enhances the proliferation of memory CD4(+) T cells. We confirm here that peripheral CD4(+)CD43(high) T cells are resistant to TCR/CD3-mediated cell death. These results suggest that the expression levels of CD43 on naive and memory CD4(+) T cells determine their susceptibility to Fas-dependent cell death and that high level expression of CD43 may be used as a marker to define CD4(+) memory T cells. Expression of CD43 provides a novel mechanism by which tumor cells expressing abnormally high levels of CD43 may escape Fas-mediated killing.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

J Exp Med

DOI

ISSN

0022-1007

Publication Date

December 20, 1999

Volume

190

Issue

12

Start / End Page

1903 / 1908

Location

United States

Related Subject Headings

  • fas Receptor
  • Signal Transduction
  • Sialoglycoproteins
  • Receptors, Antigen, T-Cell
  • Mice
  • Leukosialin
  • Immunology
  • Hybridomas
  • CD4-Positive T-Lymphocytes
  • Apoptosis
 

Citation

APA
Chicago
ICMJE
MLA
NLM
He, Y. W., & Bevan, M. J. (1999). High level expression of CD43 inhibits T cell receptor/CD3-mediated apoptosis. J Exp Med, 190(12), 1903–1908. https://doi.org/10.1084/jem.190.12.1903
He, Y. W., and M. J. Bevan. “High level expression of CD43 inhibits T cell receptor/CD3-mediated apoptosis.J Exp Med 190, no. 12 (December 20, 1999): 1903–8. https://doi.org/10.1084/jem.190.12.1903.
He YW, Bevan MJ. High level expression of CD43 inhibits T cell receptor/CD3-mediated apoptosis. J Exp Med. 1999 Dec 20;190(12):1903–8.
He, Y. W., and M. J. Bevan. “High level expression of CD43 inhibits T cell receptor/CD3-mediated apoptosis.J Exp Med, vol. 190, no. 12, Dec. 1999, pp. 1903–08. Pubmed, doi:10.1084/jem.190.12.1903.
He YW, Bevan MJ. High level expression of CD43 inhibits T cell receptor/CD3-mediated apoptosis. J Exp Med. 1999 Dec 20;190(12):1903–1908.

Published In

J Exp Med

DOI

ISSN

0022-1007

Publication Date

December 20, 1999

Volume

190

Issue

12

Start / End Page

1903 / 1908

Location

United States

Related Subject Headings

  • fas Receptor
  • Signal Transduction
  • Sialoglycoproteins
  • Receptors, Antigen, T-Cell
  • Mice
  • Leukosialin
  • Immunology
  • Hybridomas
  • CD4-Positive T-Lymphocytes
  • Apoptosis