Interleukin-7 receptor alpha is essential for the development of gamma delta + T cells, but not natural killer cells.
Publication
, Journal Article
He, YW; Malek, TR
Published in: J Exp Med
July 1, 1996
Mice that lack a functional gamma c subunit of the receptors for interleukin (IL)-2, IL-4, IL-7, IL-9, and IL-15 display profound defects in lymphoid development. The IL-7/IL-7R system represents a critical interaction for conventional T and B cell development. In this report, the role of IL-7R alpha in the development of lymphoid lineages other than conventional T and B cells was examined. We demonstrate that gamma delta + T cells were absent in IL-7R alpha-deficient mice, whereas the development and function of natural killer cells were normal. Thus, IL-7R alpha function is required for the development of gamma delta + T cells but not natural killer cells.
Duke Scholars
Published In
J Exp Med
DOI
ISSN
0022-1007
Publication Date
July 1, 1996
Volume
184
Issue
1
Start / End Page
289 / 293
Location
United States
Related Subject Headings
- Thymus Gland
- T-Lymphocyte Subsets
- Spleen
- Receptors, Interleukin-7
- Receptors, Interleukin
- Receptors, Antigen, T-Cell, gamma-delta
- Mice, Knockout
- Mice, Inbred C57BL
- Mice
- Killer Cells, Natural
Citation
APA
Chicago
ICMJE
MLA
NLM
He, Y. W., & Malek, T. R. (1996). Interleukin-7 receptor alpha is essential for the development of gamma delta + T cells, but not natural killer cells. J Exp Med, 184(1), 289–293. https://doi.org/10.1084/jem.184.1.289
He, Y. W., and T. R. Malek. “Interleukin-7 receptor alpha is essential for the development of gamma delta + T cells, but not natural killer cells.” J Exp Med 184, no. 1 (July 1, 1996): 289–93. https://doi.org/10.1084/jem.184.1.289.
He YW, Malek TR. Interleukin-7 receptor alpha is essential for the development of gamma delta + T cells, but not natural killer cells. J Exp Med. 1996 Jul 1;184(1):289–93.
He, Y. W., and T. R. Malek. “Interleukin-7 receptor alpha is essential for the development of gamma delta + T cells, but not natural killer cells.” J Exp Med, vol. 184, no. 1, July 1996, pp. 289–93. Pubmed, doi:10.1084/jem.184.1.289.
He YW, Malek TR. Interleukin-7 receptor alpha is essential for the development of gamma delta + T cells, but not natural killer cells. J Exp Med. 1996 Jul 1;184(1):289–293.
Published In
J Exp Med
DOI
ISSN
0022-1007
Publication Date
July 1, 1996
Volume
184
Issue
1
Start / End Page
289 / 293
Location
United States
Related Subject Headings
- Thymus Gland
- T-Lymphocyte Subsets
- Spleen
- Receptors, Interleukin-7
- Receptors, Interleukin
- Receptors, Antigen, T-Cell, gamma-delta
- Mice, Knockout
- Mice, Inbred C57BL
- Mice
- Killer Cells, Natural