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Mortality following blood culture in premature infants: increased with Gram-negative bacteremia and candidemia, but not Gram-positive bacteremia.

Publication ,  Journal Article
Benjamin, DK; DeLong, E; Cotten, CM; Garges, HP; Steinbach, WJ; Clark, RH
Published in: J Perinatol
March 2004

OBJECTIVE: To describe survival following nosocomial bloodstream infections and quantify excess mortality associated with positive blood culture. STUDY DESIGN: Multicenter cohort study of premature infants. RESULTS: First blood culture was negative for 4648/5497 (78%) of the neonates--390/4648 (8%) died prior to discharge. Mortality prior to discharge was 19% in the 161 infants with Gram-negative rod (GNR) bacteremia, 8% in the 854 neonates with coagulase negative staphylococcus (CONS), 6% in the 169 infants infected with other Gram-positive bacteria (GP-o), and 26% in the 115 neonates with candidemia. The excess 7-day mortality was 0% for Gram-positive organisms and 83% for GNR bacteremia and candidemia. Using negative blood culture as referent, GNR [hazard ratio (HR)=2.61] and candidemia (HR=2.27) were associated with increased mortality; CONS (HR=1.08) and GP-o (HR=0.97) were not. CONCLUSIONS: Nosocomial GNR bacteremia and candidemia were associated with increased mortality but Gram-positive bacteremia was not.

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Published In

J Perinatol

DOI

ISSN

0743-8346

Publication Date

March 2004

Volume

24

Issue

3

Start / End Page

175 / 180

Location

United States

Related Subject Headings

  • Regression Analysis
  • Proportional Hazards Models
  • Pediatrics
  • Multivariate Analysis
  • Humans
  • Gestational Age
  • Candidiasis
  • Bacteremia
  • 3213 Paediatrics
  • 1114 Paediatrics and Reproductive Medicine
 

Citation

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Benjamin, D. K., DeLong, E., Cotten, C. M., Garges, H. P., Steinbach, W. J., & Clark, R. H. (2004). Mortality following blood culture in premature infants: increased with Gram-negative bacteremia and candidemia, but not Gram-positive bacteremia. J Perinatol, 24(3), 175–180. https://doi.org/10.1038/sj.jp.7211068
Benjamin, Daniel K., Elizabeth DeLong, Charles M. Cotten, Harmony P. Garges, William J. Steinbach, and Reese H. Clark. “Mortality following blood culture in premature infants: increased with Gram-negative bacteremia and candidemia, but not Gram-positive bacteremia.J Perinatol 24, no. 3 (March 2004): 175–80. https://doi.org/10.1038/sj.jp.7211068.
Benjamin DK, DeLong E, Cotten CM, Garges HP, Steinbach WJ, Clark RH. Mortality following blood culture in premature infants: increased with Gram-negative bacteremia and candidemia, but not Gram-positive bacteremia. J Perinatol. 2004 Mar;24(3):175–80.
Benjamin, Daniel K., et al. “Mortality following blood culture in premature infants: increased with Gram-negative bacteremia and candidemia, but not Gram-positive bacteremia.J Perinatol, vol. 24, no. 3, Mar. 2004, pp. 175–80. Pubmed, doi:10.1038/sj.jp.7211068.
Benjamin DK, DeLong E, Cotten CM, Garges HP, Steinbach WJ, Clark RH. Mortality following blood culture in premature infants: increased with Gram-negative bacteremia and candidemia, but not Gram-positive bacteremia. J Perinatol. 2004 Mar;24(3):175–180.

Published In

J Perinatol

DOI

ISSN

0743-8346

Publication Date

March 2004

Volume

24

Issue

3

Start / End Page

175 / 180

Location

United States

Related Subject Headings

  • Regression Analysis
  • Proportional Hazards Models
  • Pediatrics
  • Multivariate Analysis
  • Humans
  • Gestational Age
  • Candidiasis
  • Bacteremia
  • 3213 Paediatrics
  • 1114 Paediatrics and Reproductive Medicine