Ca(2+)/CaM-dependent kinases: from activation to function.
Publication
, Journal Article
Hook, SS; Means, AR
Published in: Annu Rev Pharmacol Toxicol
2001
Calmodulin (CaM) is an essential protein that serves as a ubiquitous intracellular receptor for Ca(2+). The Ca(2+)/CaM complex initiates a plethora of signaling cascades that culminate in alteration of cellular functions. Among the many Ca(2+)/CaM-binding proteins to be discovered, the multifunctional protein kinases CaMKI, II, and IV play pivotal roles. Our review focuses on this class of CaM kinases to illustrate the structural and biochemical basis for Ca(2+)/CaM interaction with and regulation of its target enzymes. Gene transcription has been chosen as the functional endpoint to illustrate the recent advances in Ca(2+)/CaM-mediated signal transduction mechanisms.
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Published In
Annu Rev Pharmacol Toxicol
DOI
ISSN
0362-1642
Publication Date
2001
Volume
41
Start / End Page
471 / 505
Location
United States
Related Subject Headings
- Pharmacology & Pharmacy
- Molecular Sequence Data
- Humans
- Enzyme Activation
- Calcium-Calmodulin-Dependent Protein Kinases
- Calcium Signaling
- Animals
- Amino Acid Sequence
- 3214 Pharmacology and pharmaceutical sciences
- 11 Medical and Health Sciences
Citation
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Chicago
ICMJE
MLA
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Hook, S. S., & Means, A. R. (2001). Ca(2+)/CaM-dependent kinases: from activation to function. Annu Rev Pharmacol Toxicol, 41, 471–505. https://doi.org/10.1146/annurev.pharmtox.41.1.471
Hook, S. S., and A. R. Means. “Ca(2+)/CaM-dependent kinases: from activation to function.” Annu Rev Pharmacol Toxicol 41 (2001): 471–505. https://doi.org/10.1146/annurev.pharmtox.41.1.471.
Hook SS, Means AR. Ca(2+)/CaM-dependent kinases: from activation to function. Annu Rev Pharmacol Toxicol. 2001;41:471–505.
Hook, S. S., and A. R. Means. “Ca(2+)/CaM-dependent kinases: from activation to function.” Annu Rev Pharmacol Toxicol, vol. 41, 2001, pp. 471–505. Pubmed, doi:10.1146/annurev.pharmtox.41.1.471.
Hook SS, Means AR. Ca(2+)/CaM-dependent kinases: from activation to function. Annu Rev Pharmacol Toxicol. 2001;41:471–505.
Published In
Annu Rev Pharmacol Toxicol
DOI
ISSN
0362-1642
Publication Date
2001
Volume
41
Start / End Page
471 / 505
Location
United States
Related Subject Headings
- Pharmacology & Pharmacy
- Molecular Sequence Data
- Humans
- Enzyme Activation
- Calcium-Calmodulin-Dependent Protein Kinases
- Calcium Signaling
- Animals
- Amino Acid Sequence
- 3214 Pharmacology and pharmaceutical sciences
- 11 Medical and Health Sciences