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The peptidyl-prolyl isomerase Pin1.

Publication ,  Journal Article
Joseph, JD; Yeh, ES; Swenson, KI; Means, AR; Winkler,
Published in: Prog Cell Cycle Res
2003

The phospho-Ser/Thr-Pro specific prolyl-isomerase Pin1 has been implicated in multiple aspects of cell cycle regulation. It has been suggested that Pin1 function is required for both normal mitotic progression and reentry into the cell cycle from quiescence. In support of this hypothesis, numerous key regulators of G1 and mitosis have been identified as Pin1 interacting proteins. However, the cellular consequence of Pin1 binding to these proteins has rarely been rigorously characterized. In this review we focus on the role of Pin1 and its binding proteins in cell cycle regulation and the potential value of Pin1 as a therapeutic target.

Duke Scholars

Published In

Prog Cell Cycle Res

ISSN

1087-2957

Publication Date

2003

Volume

5

Start / End Page

477 / 487

Location

France

Related Subject Headings

  • Protein Binding
  • Peptidylprolyl Isomerase
  • Neoplasms
  • NIMA-Interacting Peptidylprolyl Isomerase
  • Mitosis
  • Humans
  • G1 Phase
  • Cell Cycle Proteins
  • Cell Cycle
  • Animals
 

Citation

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MLA
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Joseph, J. D., Yeh, E. S., Swenson, K. I., Means, A. R., & Winkler, . (2003). The peptidyl-prolyl isomerase Pin1. Prog Cell Cycle Res, 5, 477–487.
Joseph, James D., Elisabeth S. Yeh, Katherine I. Swenson, Anthony R. Means, and Anthony R. Winkler. “The peptidyl-prolyl isomerase Pin1.Prog Cell Cycle Res 5 (2003): 477–87.
Joseph JD, Yeh ES, Swenson KI, Means AR, Winkler. The peptidyl-prolyl isomerase Pin1. Prog Cell Cycle Res. 2003;5:477–87.
Joseph, James D., et al. “The peptidyl-prolyl isomerase Pin1.Prog Cell Cycle Res, vol. 5, 2003, pp. 477–87.
Joseph JD, Yeh ES, Swenson KI, Means AR, Winkler. The peptidyl-prolyl isomerase Pin1. Prog Cell Cycle Res. 2003;5:477–487.

Published In

Prog Cell Cycle Res

ISSN

1087-2957

Publication Date

2003

Volume

5

Start / End Page

477 / 487

Location

France

Related Subject Headings

  • Protein Binding
  • Peptidylprolyl Isomerase
  • Neoplasms
  • NIMA-Interacting Peptidylprolyl Isomerase
  • Mitosis
  • Humans
  • G1 Phase
  • Cell Cycle Proteins
  • Cell Cycle
  • Animals