Regulatory functions of calmodulin.
Publication
, Journal Article
Means, AR; VanBerkum, MF; Bagchi, I; Lu, KP; Rasmussen, CD
Published in: Pharmacol Ther
1991
Calmodulin is a Ca2+ binding protein present in all eukaryotic cells that serves as the primary intracellular receptor for Ca2+. This 148 amino acid protein is involved in activation of more than 20 enzymes which mediate a wide variety of physiological processes. Many of these enzymes are inhibited in an intramolecular manner and the Ca(2+)-calmodulin complex relieves this inhibition. Calmodulin is essential for life as disruption of the gene in genetically tractable organisms is lethal. This protein plays important regulatory roles in cell proliferation and is required at multiple points in the cell cycle. The mechanism of enzyme activation by calmodulin and its importance in cell growth regulation are reviewed.
Duke Scholars
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Published In
Pharmacol Ther
DOI
ISSN
0163-7258
Publication Date
1991
Volume
50
Issue
2
Start / End Page
255 / 270
Location
England
Related Subject Headings
- Pharmacology & Pharmacy
- Myosin-Light-Chain Kinase
- Muscle, Smooth
- Humans
- Cell Division
- Cell Cycle
- Calmodulin
- Aspergillus nidulans
- Animals
- 1115 Pharmacology and Pharmaceutical Sciences
Citation
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Means, A. R., VanBerkum, M. F., Bagchi, I., Lu, K. P., & Rasmussen, C. D. (1991). Regulatory functions of calmodulin. Pharmacol Ther, 50(2), 255–270. https://doi.org/10.1016/0163-7258(91)90017-g
Means, A. R., M. F. VanBerkum, I. Bagchi, K. P. Lu, and C. D. Rasmussen. “Regulatory functions of calmodulin.” Pharmacol Ther 50, no. 2 (1991): 255–70. https://doi.org/10.1016/0163-7258(91)90017-g.
Means AR, VanBerkum MF, Bagchi I, Lu KP, Rasmussen CD. Regulatory functions of calmodulin. Pharmacol Ther. 1991;50(2):255–70.
Means, A. R., et al. “Regulatory functions of calmodulin.” Pharmacol Ther, vol. 50, no. 2, 1991, pp. 255–70. Pubmed, doi:10.1016/0163-7258(91)90017-g.
Means AR, VanBerkum MF, Bagchi I, Lu KP, Rasmussen CD. Regulatory functions of calmodulin. Pharmacol Ther. 1991;50(2):255–270.
Published In
Pharmacol Ther
DOI
ISSN
0163-7258
Publication Date
1991
Volume
50
Issue
2
Start / End Page
255 / 270
Location
England
Related Subject Headings
- Pharmacology & Pharmacy
- Myosin-Light-Chain Kinase
- Muscle, Smooth
- Humans
- Cell Division
- Cell Cycle
- Calmodulin
- Aspergillus nidulans
- Animals
- 1115 Pharmacology and Pharmaceutical Sciences