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Molecular aspects of ovarian cancer.

Publication ,  Journal Article
Wenham, RM; Lancaster, JM; Berchuck, A
Published in: Best Pract Res Clin Obstet Gynaecol
August 2002

Ovarian cancer is caused by genetic alterations that disrupt proliferation, apoptosis, senescence and DNA repair. Approximately 10% of ovarian cancers arise in women who have inherited mutations in cancer susceptibility genes (BRCA1 or BRCA2). The ability to perform genetic testing allows identification of women at increased risk who can be offered prophylactic oophorectomy or other interventions aimed at preventing ovarian cancer. The vast majority of ovarian cancers are sporadic, resulting from the accumulation of genetic damage over a lifetime. Several specific genes involved in ovarian carcinogenesis have been identified, including the p53 tumour suppressor gene and HER2/ neu andPIC3KA oncogenes. The recent availability of expression microarrays has facilitated the simultaneous examination of thousands of genes, and this promises to extend further our understanding of the molecular events involved in the development of ovarian cancers. Hopefully, this knowledge can be translated into effective screening, treatment, surveillance, and prevention strategies in the future.

Duke Scholars

Published In

Best Pract Res Clin Obstet Gynaecol

DOI

ISSN

1521-6934

Publication Date

August 2002

Volume

16

Issue

4

Start / End Page

483 / 497

Location

Netherlands

Related Subject Headings

  • Ovarian Neoplasms
  • Oncogenes
  • Obstetrics & Reproductive Medicine
  • Mutation
  • Humans
  • Genes, Tumor Suppressor
  • Female
  • Cell Transformation, Neoplastic
  • 4204 Midwifery
  • 3215 Reproductive medicine
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wenham, R. M., Lancaster, J. M., & Berchuck, A. (2002). Molecular aspects of ovarian cancer. Best Pract Res Clin Obstet Gynaecol, 16(4), 483–497. https://doi.org/10.1053/beog.2002.0298
Wenham, Robert M., Johnathan M. Lancaster, and Andrew Berchuck. “Molecular aspects of ovarian cancer.Best Pract Res Clin Obstet Gynaecol 16, no. 4 (August 2002): 483–97. https://doi.org/10.1053/beog.2002.0298.
Wenham RM, Lancaster JM, Berchuck A. Molecular aspects of ovarian cancer. Best Pract Res Clin Obstet Gynaecol. 2002 Aug;16(4):483–97.
Wenham, Robert M., et al. “Molecular aspects of ovarian cancer.Best Pract Res Clin Obstet Gynaecol, vol. 16, no. 4, Aug. 2002, pp. 483–97. Pubmed, doi:10.1053/beog.2002.0298.
Wenham RM, Lancaster JM, Berchuck A. Molecular aspects of ovarian cancer. Best Pract Res Clin Obstet Gynaecol. 2002 Aug;16(4):483–497.
Journal cover image

Published In

Best Pract Res Clin Obstet Gynaecol

DOI

ISSN

1521-6934

Publication Date

August 2002

Volume

16

Issue

4

Start / End Page

483 / 497

Location

Netherlands

Related Subject Headings

  • Ovarian Neoplasms
  • Oncogenes
  • Obstetrics & Reproductive Medicine
  • Mutation
  • Humans
  • Genes, Tumor Suppressor
  • Female
  • Cell Transformation, Neoplastic
  • 4204 Midwifery
  • 3215 Reproductive medicine