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Bcl10 is not a target for frequent mutation in human carcinomas.

Publication ,  Journal Article
Lambers, AR; Gumbs, C; Ali, S; Marks, JR; Iglehart, JD; Berchuck, A; Futreal, PA
Published in: Br J Cancer
July 1999

The recently described Bcl10 gene has been suggested to be a major target gene for inactivation in a variety of human cancers. In order to further evaluate the role of this gene in human adult malignancies, we have analysed a series of carcinomas for mutations in the Bcl10 gene. We have screened a panel of 174 carcinoma samples in total, comprised of 47 breast, 36 epithelial ovarian, 36 endometrial, 12 cervical, 23 colorectal and 20 head/neck carcinomas, all unselected for grade or stage. This panel reflects, in part, tumours reported to have involvement of the 1p22 region of chromosome 1, the region harbouring the Bcl10 gene. No deleterious mutations were detected in any of the samples analysed, strongly suggesting that Bcl10 is not a common target for inactivation in adult malignancies and that BCL10 is not the gene targeted for frequent inactivation at 1p22.

Duke Scholars

Published In

Br J Cancer

DOI

ISSN

0007-0920

Publication Date

July 1999

Volume

80

Issue

10

Start / End Page

1575 / 1576

Location

England

Related Subject Headings

  • Polymorphism, Single-Stranded Conformational
  • Polymerase Chain Reaction
  • Oncology & Carcinogenesis
  • Neoplasm Proteins
  • Mutation
  • Humans
  • Head and Neck Neoplasms
  • Genital Neoplasms, Female
  • Female
  • Colorectal Neoplasms
 

Citation

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Lambers, A. R., Gumbs, C., Ali, S., Marks, J. R., Iglehart, J. D., Berchuck, A., & Futreal, P. A. (1999). Bcl10 is not a target for frequent mutation in human carcinomas. Br J Cancer, 80(10), 1575–1576. https://doi.org/10.1038/sj.bjc.6690564
Lambers, A. R., C. Gumbs, S. Ali, J. R. Marks, J. D. Iglehart, A. Berchuck, and P. A. Futreal. “Bcl10 is not a target for frequent mutation in human carcinomas.Br J Cancer 80, no. 10 (July 1999): 1575–76. https://doi.org/10.1038/sj.bjc.6690564.
Lambers AR, Gumbs C, Ali S, Marks JR, Iglehart JD, Berchuck A, et al. Bcl10 is not a target for frequent mutation in human carcinomas. Br J Cancer. 1999 Jul;80(10):1575–6.
Lambers, A. R., et al. “Bcl10 is not a target for frequent mutation in human carcinomas.Br J Cancer, vol. 80, no. 10, July 1999, pp. 1575–76. Pubmed, doi:10.1038/sj.bjc.6690564.
Lambers AR, Gumbs C, Ali S, Marks JR, Iglehart JD, Berchuck A, Futreal PA. Bcl10 is not a target for frequent mutation in human carcinomas. Br J Cancer. 1999 Jul;80(10):1575–1576.

Published In

Br J Cancer

DOI

ISSN

0007-0920

Publication Date

July 1999

Volume

80

Issue

10

Start / End Page

1575 / 1576

Location

England

Related Subject Headings

  • Polymorphism, Single-Stranded Conformational
  • Polymerase Chain Reaction
  • Oncology & Carcinogenesis
  • Neoplasm Proteins
  • Mutation
  • Humans
  • Head and Neck Neoplasms
  • Genital Neoplasms, Female
  • Female
  • Colorectal Neoplasms