Immunohistochemical expression of TAG-72 in normal and malignant endometrium: correlation of antigen expression with estrogen receptor and progesterone receptor levels.
TAG-72 is a tumor-associated antigen that is expressed by secretory endometrium and most endometrial adenocarcinomas. We used immunohistochemical techniques to quantitate expression of TAG-72, estrogen receptor, and progesterone receptor in 21 normal endometria and 44 endometrial adenocarcinomas. In normal cycling endometrial glands, TAG-72 expression was related inversely to expression of receptors for estrogen and progesterone. This suggests that TAG-72 expression in normal endometrium may be hormonally regulated. Ninety-one percent of endometrial adenocarcinomas expressed immunohistochemically detectable TAG-72. The magnitude of TAG-72 expression did not correlate with other known prognostic factors in endometrial cancer such as histologic grade, depth of myometrial invasion, surgical stage, or steroid receptor status. The production of TAG-72 by most endometrial adenocarcinomas may represent nonspecific expression by cells that have dedifferentiated.
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Related Subject Headings
- Uterus
- Uterine Neoplasms
- Reference Values
- Receptors, Progesterone
- Receptors, Estrogen
- Obstetrics & Reproductive Medicine
- Middle Aged
- Immunohistochemistry
- Humans
- Glycoproteins
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Uterus
- Uterine Neoplasms
- Reference Values
- Receptors, Progesterone
- Receptors, Estrogen
- Obstetrics & Reproductive Medicine
- Middle Aged
- Immunohistochemistry
- Humans
- Glycoproteins