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The biology of ovarian cancer.

Publication ,  Journal Article
Boente, MP; Hurteau, J; Rodriguez, GC; Bast, RC; Berchuck, A
Published in: Curr Opin Oncol
September 1993

Recent studies have begun to elucidate the molecular events involved in the development of ovarian cancer. First, it has been shown that epithelial ovarian cells both produce and have receptors for many peptide growth factors. It is possible that these growth factors may participate in autocrine and paracrine growth-regulatory pathways in these cells. Increased activity of stimulatory factors, eg, transforming growth factor-alpha, or decreased activity of inhibitor factors, eg, transforming growth factor-beta, may facilitate malignant transformation. In addition, it has been shown that ovarian cancer cells often have acquired the ability to degrade extracellular matrix and invade the underlying tissues. Finally, alterations in several oncogenes and tumor-suppressor genes, including HER2/neu, c-myc, and p53, have been found in ovarian cancers. Although exciting insights into the molecular pathology of ovarian cancer have been gained, we remain far from a comprehensive understanding of the biology of this highly lethal disease.

Duke Scholars

Published In

Curr Opin Oncol

DOI

ISSN

1040-8746

Publication Date

September 1993

Volume

5

Issue

5

Start / End Page

900 / 907

Location

United States

Related Subject Headings

  • Transforming Growth Factor beta
  • Transforming Growth Factor alpha
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Oncogenes
  • Neoplasm Metastasis
  • Neoplasm Invasiveness
  • Humans
  • Genes, Tumor Suppressor
  • Female
 

Citation

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MLA
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Boente, M. P., Hurteau, J., Rodriguez, G. C., Bast, R. C., & Berchuck, A. (1993). The biology of ovarian cancer. Curr Opin Oncol, 5(5), 900–907. https://doi.org/10.1097/00001622-199309000-00020
Boente, M. P., J. Hurteau, G. C. Rodriguez, R. C. Bast, and A. Berchuck. “The biology of ovarian cancer.Curr Opin Oncol 5, no. 5 (September 1993): 900–907. https://doi.org/10.1097/00001622-199309000-00020.
Boente MP, Hurteau J, Rodriguez GC, Bast RC, Berchuck A. The biology of ovarian cancer. Curr Opin Oncol. 1993 Sep;5(5):900–7.
Boente, M. P., et al. “The biology of ovarian cancer.Curr Opin Oncol, vol. 5, no. 5, Sept. 1993, pp. 900–07. Pubmed, doi:10.1097/00001622-199309000-00020.
Boente MP, Hurteau J, Rodriguez GC, Bast RC, Berchuck A. The biology of ovarian cancer. Curr Opin Oncol. 1993 Sep;5(5):900–907.

Published In

Curr Opin Oncol

DOI

ISSN

1040-8746

Publication Date

September 1993

Volume

5

Issue

5

Start / End Page

900 / 907

Location

United States

Related Subject Headings

  • Transforming Growth Factor beta
  • Transforming Growth Factor alpha
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Oncogenes
  • Neoplasm Metastasis
  • Neoplasm Invasiveness
  • Humans
  • Genes, Tumor Suppressor
  • Female