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Biomarkers in the ovary.

Publication ,  Journal Article
Berchuck, A
Published in: J Cell Biochem Suppl
1995

Alterations in specific oncogenes and tumor suppressor genes that serve as surrogate markers of malignant transformation have been identified in ovarian cancers. Overexpression of the HER-2/neu oncogene occurs in approximately 30% of breast and ovarian cancers. In most studies, HER-2/neu overexpression has correlated with poor survival. Although mutation of the K-ras oncogene has been found in some mucinous ovarian cancers, mutations in this gene appear to be more common in borderline ovarian tumors. Amplification of c-myc occurs in approximately 30% of ovarian cancers and is more frequently seen in serous cancers. Mutation of the p53 tumor suppressor gene, with resultant overexpression of mutant p53 protein, occurs in 50% of Stage III/IV and 15% of Stage I/II ovarian cancers. Most p53 mutations in ovarian cancers are transitions, which suggests that they arise spontaneously rather than due to exogenous carcinogens. In contrast to the acquired genetic alterations described above that are a feature of sporadic ovarian cancers, a small fraction of epithelial ovarian cancers arise due to inherited genetic defects. Recently, the BRCA1 tumor suppressor gene on chromosome 17q was identified and shown to be responsible for some cases of hereditary breast and ovarian cancer. Families in which mutations in this gene exist are usually characterized by early age of disease onset. Presently, it remains unclear what fraction of hereditary ovarian cancers are due to BRCA1 mutations.

Duke Scholars

Published In

J Cell Biochem Suppl

ISSN

0733-1959

Publication Date

1995

Volume

23

Start / End Page

223 / 226

Location

United States

Related Subject Headings

  • Predictive Value of Tests
  • Ovarian Neoplasms
  • Oncogenes
  • Humans
  • Genes, Tumor Suppressor
  • Female
  • Cell Transformation, Neoplastic
  • Biomarkers, Tumor
 

Citation

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Chicago
ICMJE
MLA
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Berchuck, A. (1995). Biomarkers in the ovary. J Cell Biochem Suppl, 23, 223–226.
Berchuck, A. “Biomarkers in the ovary.J Cell Biochem Suppl 23 (1995): 223–26.
Berchuck A. Biomarkers in the ovary. J Cell Biochem Suppl. 1995;23:223–6.
Berchuck, A. “Biomarkers in the ovary.J Cell Biochem Suppl, vol. 23, 1995, pp. 223–26.
Berchuck A. Biomarkers in the ovary. J Cell Biochem Suppl. 1995;23:223–226.

Published In

J Cell Biochem Suppl

ISSN

0733-1959

Publication Date

1995

Volume

23

Start / End Page

223 / 226

Location

United States

Related Subject Headings

  • Predictive Value of Tests
  • Ovarian Neoplasms
  • Oncogenes
  • Humans
  • Genes, Tumor Suppressor
  • Female
  • Cell Transformation, Neoplastic
  • Biomarkers, Tumor