New series of aryloxypropanolamines with both human beta(3)-adrenoceptor agonistic activity and free radical scavenging properties.
Publication
, Journal Article
Aubriot, S; Nicolle, E; Lattier, M; Morel, C; Cao, W; Daniel, KW; Collins, S; Leclerc, G; Faure, P
Published in: Bioorg Med Chem Lett
January 21, 2002
A series of 13 novel hybrid molecules designed to possess both free radical scavenging activity and to stimulate the beta(3)-adrenoceptors in order to improve antidiabetic effect and to restore insulin sensitivity was synthesized and evaluated. Compounds were of quinolyl-, isoquinolyl-, pyridoindolyl- or carbazolyloxypropanolamine structure with a terminal amino group of benzopyranolyl-, di-tert-butylphenolyl- or methoxyindolyl-type. Some of the products possessed both the expected activities.
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
Bioorg Med Chem Lett
DOI
ISSN
0960-894X
Publication Date
January 21, 2002
Volume
12
Issue
2
Start / End Page
209 / 212
Location
England
Related Subject Headings
- Propanolamines
- Medicinal & Biomolecular Chemistry
- Humans
- Free Radical Scavengers
- COS Cells
- Animals
- Adrenergic beta-Agonists
- Adrenergic beta-3 Receptor Agonists
- 3405 Organic chemistry
- 3404 Medicinal and biomolecular chemistry
Citation
APA
Chicago
ICMJE
MLA
NLM
Aubriot, S., Nicolle, E., Lattier, M., Morel, C., Cao, W., Daniel, K. W., … Faure, P. (2002). New series of aryloxypropanolamines with both human beta(3)-adrenoceptor agonistic activity and free radical scavenging properties. Bioorg Med Chem Lett, 12(2), 209–212. https://doi.org/10.1016/s0960-894x(01)00716-8
Aubriot, Silvère, Edwige Nicolle, Mireille Lattier, Cécile Morel, Wenhong Cao, Kiefer W. Daniel, Sheila Collins, Gérard Leclerc, and Patrice Faure. “New series of aryloxypropanolamines with both human beta(3)-adrenoceptor agonistic activity and free radical scavenging properties.” Bioorg Med Chem Lett 12, no. 2 (January 21, 2002): 209–12. https://doi.org/10.1016/s0960-894x(01)00716-8.
Aubriot S, Nicolle E, Lattier M, Morel C, Cao W, Daniel KW, et al. New series of aryloxypropanolamines with both human beta(3)-adrenoceptor agonistic activity and free radical scavenging properties. Bioorg Med Chem Lett. 2002 Jan 21;12(2):209–12.
Aubriot, Silvère, et al. “New series of aryloxypropanolamines with both human beta(3)-adrenoceptor agonistic activity and free radical scavenging properties.” Bioorg Med Chem Lett, vol. 12, no. 2, Jan. 2002, pp. 209–12. Pubmed, doi:10.1016/s0960-894x(01)00716-8.
Aubriot S, Nicolle E, Lattier M, Morel C, Cao W, Daniel KW, Collins S, Leclerc G, Faure P. New series of aryloxypropanolamines with both human beta(3)-adrenoceptor agonistic activity and free radical scavenging properties. Bioorg Med Chem Lett. 2002 Jan 21;12(2):209–212.
Published In
Bioorg Med Chem Lett
DOI
ISSN
0960-894X
Publication Date
January 21, 2002
Volume
12
Issue
2
Start / End Page
209 / 212
Location
England
Related Subject Headings
- Propanolamines
- Medicinal & Biomolecular Chemistry
- Humans
- Free Radical Scavengers
- COS Cells
- Animals
- Adrenergic beta-Agonists
- Adrenergic beta-3 Receptor Agonists
- 3405 Organic chemistry
- 3404 Medicinal and biomolecular chemistry