Genetic vulnerability to diet-induced obesity in the C57BL/6J mouse: physiological and molecular characteristics.
Publication
, Journal Article
Collins, S; Martin, TL; Surwit, RS; Robidoux, J
Published in: Physiol Behav
April 2004
The development of the metabolic syndrome in an increasing percentage of the populations of Western societies, particularly in the United States, requires valid models for establishing basic biochemical changes and performing preclinical studies on potential drug targets. The C57BL/6J mouse has become an important model for understanding the interplay between genetic background and environmental challenges such as high-fat/high-calorie diets that predispose to the development of the metabolic syndrome. This review highlights metabolic and signal transduction features that are altered during the course of disease progression, many of which mirror the human situation.
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Published In
Physiol Behav
DOI
ISSN
0031-9384
Publication Date
April 2004
Volume
81
Issue
2
Start / End Page
243 / 248
Location
United States
Related Subject Headings
- Signal Transduction
- Obesity
- Mice, Inbred C57BL
- Mice
- Genetic Predisposition to Disease
- Diet
- Catecholamines
- Behavioral Science & Comparative Psychology
- Animals
- Adipose Tissue
Citation
APA
Chicago
ICMJE
MLA
NLM
Collins, S., Martin, T. L., Surwit, R. S., & Robidoux, J. (2004). Genetic vulnerability to diet-induced obesity in the C57BL/6J mouse: physiological and molecular characteristics. Physiol Behav, 81(2), 243–248. https://doi.org/10.1016/j.physbeh.2004.02.006
Collins, Sheila, Tonya L. Martin, Richard S. Surwit, and Jacques Robidoux. “Genetic vulnerability to diet-induced obesity in the C57BL/6J mouse: physiological and molecular characteristics.” Physiol Behav 81, no. 2 (April 2004): 243–48. https://doi.org/10.1016/j.physbeh.2004.02.006.
Collins S, Martin TL, Surwit RS, Robidoux J. Genetic vulnerability to diet-induced obesity in the C57BL/6J mouse: physiological and molecular characteristics. Physiol Behav. 2004 Apr;81(2):243–8.
Collins, Sheila, et al. “Genetic vulnerability to diet-induced obesity in the C57BL/6J mouse: physiological and molecular characteristics.” Physiol Behav, vol. 81, no. 2, Apr. 2004, pp. 243–48. Pubmed, doi:10.1016/j.physbeh.2004.02.006.
Collins S, Martin TL, Surwit RS, Robidoux J. Genetic vulnerability to diet-induced obesity in the C57BL/6J mouse: physiological and molecular characteristics. Physiol Behav. 2004 Apr;81(2):243–248.
Published In
Physiol Behav
DOI
ISSN
0031-9384
Publication Date
April 2004
Volume
81
Issue
2
Start / End Page
243 / 248
Location
United States
Related Subject Headings
- Signal Transduction
- Obesity
- Mice, Inbred C57BL
- Mice
- Genetic Predisposition to Disease
- Diet
- Catecholamines
- Behavioral Science & Comparative Psychology
- Animals
- Adipose Tissue