Skip to main content
Journal cover image

Lung transplantation after long-term mechanical ventilation : results and 1-year follow-up.

Publication ,  Journal Article
Baz, MA; Palmer, SM; Staples, ED; Greer, DG; Tapson, VF; Davis, DD
Published in: Chest
January 2001

BACKGROUND: Long-term mechanical ventilation is considered as a relative or absolute contraindication for lung transplantation by most centers. We report on the results of transplantation in nine patients requiring long-term mechanical ventilation at two lung transplant centers. METHODS: The study group (group 1) consisted of nine patients receiving mechanical ventilation who underwent lung transplantation at either Duke University Medical Center or the University of Florida between 1992 and 1997. Patients in group 1 met the following criteria: they underwent exercise therapy with a physical therapist, and they were without panresistant bacterial airway colonization. The study patients that met these criteria spent at least 13 days receiving mechanical ventilation prior to transplantation. The control population (group 2; n = 65) consisted of all patients who underwent transplantation at either center in the calendar year 1997 who were ventilator independent. The 1-year survival rates in each group were calculated by the Kaplan-Meier method. The number of days required for extubation in each group were compared by the nonparametric Wilcoxon rank sum test. The FEV(1) value at 1 year was reported in each group. RESULTS: The 1-year survival rates were 78% and 83% in group 1 and group 2, respectively. The mean number of days required until extubation were 41 days in group 1 and 9 days in group 2 (p < 0.01). The allograft function was comparable in the two groups at 1 year. CONCLUSIONS: In a select population of ventilator-dependent patients, the 1-year survival rate is comparable to the standard lung transplant population. However, these ventilator-dependent patients require a significantly longer time until extubation than other transplant recipients.

Duke Scholars

Published In

Chest

DOI

ISSN

0012-3692

Publication Date

January 2001

Volume

119

Issue

1

Start / End Page

224 / 227

Location

United States

Related Subject Headings

  • Ventilator Weaning
  • Survival Rate
  • Respiratory System
  • Respiration, Artificial
  • Postoperative Complications
  • Middle Aged
  • Male
  • Lung Transplantation
  • Long-Term Care
  • Length of Stay
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Baz, M. A., Palmer, S. M., Staples, E. D., Greer, D. G., Tapson, V. F., & Davis, D. D. (2001). Lung transplantation after long-term mechanical ventilation : results and 1-year follow-up. Chest, 119(1), 224–227. https://doi.org/10.1378/chest.119.1.224
Baz, M. A., S. M. Palmer, E. D. Staples, D. G. Greer, V. F. Tapson, and D. D. Davis. “Lung transplantation after long-term mechanical ventilation : results and 1-year follow-up.Chest 119, no. 1 (January 2001): 224–27. https://doi.org/10.1378/chest.119.1.224.
Baz MA, Palmer SM, Staples ED, Greer DG, Tapson VF, Davis DD. Lung transplantation after long-term mechanical ventilation : results and 1-year follow-up. Chest. 2001 Jan;119(1):224–7.
Baz, M. A., et al. “Lung transplantation after long-term mechanical ventilation : results and 1-year follow-up.Chest, vol. 119, no. 1, Jan. 2001, pp. 224–27. Pubmed, doi:10.1378/chest.119.1.224.
Baz MA, Palmer SM, Staples ED, Greer DG, Tapson VF, Davis DD. Lung transplantation after long-term mechanical ventilation : results and 1-year follow-up. Chest. 2001 Jan;119(1):224–227.
Journal cover image

Published In

Chest

DOI

ISSN

0012-3692

Publication Date

January 2001

Volume

119

Issue

1

Start / End Page

224 / 227

Location

United States

Related Subject Headings

  • Ventilator Weaning
  • Survival Rate
  • Respiratory System
  • Respiration, Artificial
  • Postoperative Complications
  • Middle Aged
  • Male
  • Lung Transplantation
  • Long-Term Care
  • Length of Stay