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A cell surface receptor mediates extracellular Ca(2+) sensing in guard cells.

Publication ,  Journal Article
Han, S; Tang, R; Anderson, LK; Woerner, TE; Pei, Z-M
Published in: Nature
September 2003

Extracellular Ca(2+) (Ca(2+)(o)) is required for various physiological and developmental processes in animals and plants. In response to varied Ca(2+)(o) levels, plants maintain relatively constant internal Ca(2+) content, suggesting a precise regulatory mechanism for Ca(2+) homeostasis. However, little is known about how plants monitor Ca(2+)(o) status and whether Ca(2+)(o)-sensing receptors exist. The effects of Ca(2+)(o) on guard cells in promoting stomatal closure by inducing increases in the concentration of cytosolic Ca(2+) ([Ca(2+)](i)) provide a clue to Ca(2+)(o) sensing. Here we have used a functional screening assay in mammalian cells to isolate an Arabidopsis complementary DNA clone encoding a Ca(2+)-sensing receptor, CAS. CAS is localized to the plasma membrane, exhibits low-affinity/high-capacity Ca(2+) binding, and mediates Ca(2+)(o)-induced [Ca(2+)](i) increases. CAS is expressed predominantly in the shoot, including guard cells. Repression of CAS disrupts Ca(2+)(o) signalling in guard cells, and impairs bolting (swift upward growth at the transition to seed production) in response to Ca(2+) deficiency, so we conclude that CAS may be a primary transducer of Ca(2+)(o) in plants.

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Published In

Nature

DOI

EISSN

1476-4687

ISSN

0028-0836

Publication Date

September 2003

Volume

425

Issue

6954

Start / End Page

196 / 200

Related Subject Headings

  • Receptors, Cell Surface
  • Receptors, Calcium-Sensing
  • RNA, Messenger
  • Protein Transport
  • Molecular Sequence Data
  • Humans
  • Homeostasis
  • Genes, Plant
  • General Science & Technology
  • Gene Expression Profiling
 

Citation

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Han, S., Tang, R., Anderson, L. K., Woerner, T. E., & Pei, Z.-M. (2003). A cell surface receptor mediates extracellular Ca(2+) sensing in guard cells. Nature, 425(6954), 196–200. https://doi.org/10.1038/nature01932
Han, Shengcheng, Ruhang Tang, Lisa K. Anderson, Todd E. Woerner, and Zhen-Ming Pei. “A cell surface receptor mediates extracellular Ca(2+) sensing in guard cells.Nature 425, no. 6954 (September 2003): 196–200. https://doi.org/10.1038/nature01932.
Han S, Tang R, Anderson LK, Woerner TE, Pei Z-M. A cell surface receptor mediates extracellular Ca(2+) sensing in guard cells. Nature. 2003 Sep;425(6954):196–200.
Han, Shengcheng, et al. “A cell surface receptor mediates extracellular Ca(2+) sensing in guard cells.Nature, vol. 425, no. 6954, Sept. 2003, pp. 196–200. Epmc, doi:10.1038/nature01932.
Han S, Tang R, Anderson LK, Woerner TE, Pei Z-M. A cell surface receptor mediates extracellular Ca(2+) sensing in guard cells. Nature. 2003 Sep;425(6954):196–200.
Journal cover image

Published In

Nature

DOI

EISSN

1476-4687

ISSN

0028-0836

Publication Date

September 2003

Volume

425

Issue

6954

Start / End Page

196 / 200

Related Subject Headings

  • Receptors, Cell Surface
  • Receptors, Calcium-Sensing
  • RNA, Messenger
  • Protein Transport
  • Molecular Sequence Data
  • Humans
  • Homeostasis
  • Genes, Plant
  • General Science & Technology
  • Gene Expression Profiling