The immunohistochemical profile of the tethered filum terminale.
Publication
, Journal Article
George, TM; Bulsara, KR; Cummings, TJ
Published in: Pediatr Neurosurg
November 2003
The embryopathy underlying tethering of the filum terminale is poorly understood. Knowledge of normal filum development is the foundation upon which to compare normal fila to fila from patients with tethered cord syndrome. Thirty-four fila from patients with tethered cord syndrome were immunostained with caudal neural tube developmental markers H4C4 (CD44), VIN-IS-53, AC4, FP3 and NOT1, and a panel of mature neuroglial, neural crest, epithelial and mesenchymal markers. H4C4 (CD44) and NOT1 exhibited significant alterations in immunoexpression in tethered fila compared to controls. The change in expression may be indicative of altered cell identity in the filum and constitute the predisposition to tethering.
Duke Scholars
Published In
Pediatr Neurosurg
DOI
ISSN
1016-2291
Publication Date
November 2003
Volume
39
Issue
5
Start / End Page
227 / 233
Location
Switzerland
Related Subject Headings
- Neurology & Neurosurgery
- Neural Tube Defects
- Middle Aged
- Male
- Infant, Newborn
- Infant
- Immunohistochemistry
- Humans
- Female
- Child, Preschool
Citation
APA
Chicago
ICMJE
MLA
NLM
George, T. M., Bulsara, K. R., & Cummings, T. J. (2003). The immunohistochemical profile of the tethered filum terminale. Pediatr Neurosurg, 39(5), 227–233. https://doi.org/10.1159/000072866
George, Timothy M., Ketan R. Bulsara, and Thomas J. Cummings. “The immunohistochemical profile of the tethered filum terminale.” Pediatr Neurosurg 39, no. 5 (November 2003): 227–33. https://doi.org/10.1159/000072866.
George TM, Bulsara KR, Cummings TJ. The immunohistochemical profile of the tethered filum terminale. Pediatr Neurosurg. 2003 Nov;39(5):227–33.
George, Timothy M., et al. “The immunohistochemical profile of the tethered filum terminale.” Pediatr Neurosurg, vol. 39, no. 5, Nov. 2003, pp. 227–33. Pubmed, doi:10.1159/000072866.
George TM, Bulsara KR, Cummings TJ. The immunohistochemical profile of the tethered filum terminale. Pediatr Neurosurg. 2003 Nov;39(5):227–233.
Published In
Pediatr Neurosurg
DOI
ISSN
1016-2291
Publication Date
November 2003
Volume
39
Issue
5
Start / End Page
227 / 233
Location
Switzerland
Related Subject Headings
- Neurology & Neurosurgery
- Neural Tube Defects
- Middle Aged
- Male
- Infant, Newborn
- Infant
- Immunohistochemistry
- Humans
- Female
- Child, Preschool