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Lymphomas and high-grade astrocytomas: comparison of water diffusibility and histologic characteristics.

Publication ,  Journal Article
Guo, AC; Cummings, TJ; Dash, RC; Provenzale, JM
Published in: Radiology
July 2002

PURPOSE: To determine if water diffusivity within lymphomas and high-grade astrocytomas correlates with cellularity. MATERIALS AND METHODS: Echo-planar diffusion-weighted magnetic resonance (MR) images obtained in 11 patients with brain lymphomas (19 lesions) and in 17 patients with astrocytomas (19 lesions) were retrospectively reviewed. Regions of interest were drawn on apparent diffusion coefficient (ADC) maps in enhancing tumor. ADC values were normalized by dividing ADC values of tumors by those of normal-appearing regions and expressing the quotient as a ratio. Histologic samples from 11 patients with astrocytomas (11 lesions) and seven patients with lymphoma (seven lesions) were reviewed. Cellularity was measured by calculating the percentage of nuclear area and the percentage of cytoplasmic area and expressing the results as the nuclear-to-cytoplasmic (N/C) ratio. The ADC and N/C ratios of both tumor types were compared by using a two-tailed t test. RESULTS: Mean ADC ratio of lymphomas was 1.15 (SD, 0.33; standard error of the mean [SEM], 0.10), and that of high-grade astrocytomas was 1.68 (SD, 0.48; SEM, 0.11) (P <.01). Mean N/C ratio of lymphoma was 1.45 (SD, 0.94; SEM, 0.36), and that of high-grade astrocytomas was 0.24 (SD, 0.18; SEM, 0.05) (P <.01). CONCLUSION: Measurements of water diffusivity and cellularity suggest that higher cellularity contributes to more restricted diffusion.

Duke Scholars

Published In

Radiology

DOI

ISSN

0033-8419

Publication Date

July 2002

Volume

224

Issue

1

Start / End Page

177 / 183

Location

United States

Related Subject Headings

  • Water
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Lymphoma
  • Humans
  • Female
  • Echo-Planar Imaging
  • Diffusion
  • Brain Neoplasms
 

Citation

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MLA
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Guo, A. C., Cummings, T. J., Dash, R. C., & Provenzale, J. M. (2002). Lymphomas and high-grade astrocytomas: comparison of water diffusibility and histologic characteristics. Radiology, 224(1), 177–183. https://doi.org/10.1148/radiol.2241010637
Guo, Alexander C., Thomas J. Cummings, Rajesh C. Dash, and James M. Provenzale. “Lymphomas and high-grade astrocytomas: comparison of water diffusibility and histologic characteristics.Radiology 224, no. 1 (July 2002): 177–83. https://doi.org/10.1148/radiol.2241010637.
Guo AC, Cummings TJ, Dash RC, Provenzale JM. Lymphomas and high-grade astrocytomas: comparison of water diffusibility and histologic characteristics. Radiology. 2002 Jul;224(1):177–83.
Guo, Alexander C., et al. “Lymphomas and high-grade astrocytomas: comparison of water diffusibility and histologic characteristics.Radiology, vol. 224, no. 1, July 2002, pp. 177–83. Pubmed, doi:10.1148/radiol.2241010637.
Guo AC, Cummings TJ, Dash RC, Provenzale JM. Lymphomas and high-grade astrocytomas: comparison of water diffusibility and histologic characteristics. Radiology. 2002 Jul;224(1):177–183.
Journal cover image

Published In

Radiology

DOI

ISSN

0033-8419

Publication Date

July 2002

Volume

224

Issue

1

Start / End Page

177 / 183

Location

United States

Related Subject Headings

  • Water
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Lymphoma
  • Humans
  • Female
  • Echo-Planar Imaging
  • Diffusion
  • Brain Neoplasms