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Homeostatic regulation of airway smooth muscle tone by catecholamine secretion in swine.

Publication ,  Journal Article
White, SR; Sands, MF; Popovich, KJ; Murphy, TM; Munoz, NM; Blake, J; Mack, M; Shioya, T; Leff, AR
Published in: J Appl Physiol (1985)
March 1987

We studied the homeostatic secretory response of catecholamine secretion elicited by progressive bronchoconstriction in 18 swine in vivo. The potential reserve of the sympathetic nervous system (SNS) was first assessed by exogenous nicotinic stimulation with 1,1-dimethyl-4-phenylpiperazinium iodide (DMPP). A dose of 250 micrograms/kg iv DMPP caused an increase in plasma norepinephrine (NE) concentration from 207 +/- 86 (basal) to 2,625 +/- 448 pg/ml (P less than 0.02) and in plasma epinephrine (EPI) from 10 +/- 5.0 to 1,410 +/- 432 pg/ml (P less than 0.05) in four swine. In four other swine, bronchoconstriction induced by aerosolized prostaglandin F2 alpha caused approximately a fivefold increase in airway resistance without hemodynamic changes. No increase in plasma EPI was observed. However, plasma NE increased from 330 +/- 131 to 1,540 +/- 182 pg/ml (P less than 0.02). In five swine receiving aerosolized acetylcholine (ACh), similar changes in airways resistance were not associated with significant changes in catecholamine concentration when mean arterial blood pressure (MAP) was unchanged. However, inhalation of sufficient ACh to cause a greater than 10% decrease in MAP caused progressive increase in catecholamine secretion. Plasma EPI increased from 32 +/- 16 (MAP = 124 +/- 7 Torr) to 1,165 +/- 522 pg/ml (MAP = 94 +/- Torr). Hypoxemia that occurred with bronchoconstriction (greater than or equal to 50 Torr) did not cause catecholamine secretion. However, severe hypoxemia (PO2 less than 30 Torr) caused large increases in plasma EPI concentrations from 84 +/- 27 to 1,463 +/- 945 pg/ml (P less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)

Duke Scholars

Published In

J Appl Physiol (1985)

DOI

ISSN

8750-7587

Publication Date

March 1987

Volume

62

Issue

3

Start / End Page

972 / 977

Location

United States

Related Subject Headings

  • Sympathetic Nervous System
  • Swine
  • Respiratory System
  • Respiratory Physiological Phenomena
  • Prostaglandins F
  • Physiology
  • Norepinephrine
  • Muscle, Smooth
  • Male
  • Kinetics
 

Citation

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White, S. R., Sands, M. F., Popovich, K. J., Murphy, T. M., Munoz, N. M., Blake, J., … Leff, A. R. (1987). Homeostatic regulation of airway smooth muscle tone by catecholamine secretion in swine. J Appl Physiol (1985), 62(3), 972–977. https://doi.org/10.1152/jappl.1987.62.3.972
White, S. R., M. F. Sands, K. J. Popovich, T. M. Murphy, N. M. Munoz, J. Blake, M. Mack, T. Shioya, and A. R. Leff. “Homeostatic regulation of airway smooth muscle tone by catecholamine secretion in swine.J Appl Physiol (1985) 62, no. 3 (March 1987): 972–77. https://doi.org/10.1152/jappl.1987.62.3.972.
White SR, Sands MF, Popovich KJ, Murphy TM, Munoz NM, Blake J, et al. Homeostatic regulation of airway smooth muscle tone by catecholamine secretion in swine. J Appl Physiol (1985). 1987 Mar;62(3):972–7.
White, S. R., et al. “Homeostatic regulation of airway smooth muscle tone by catecholamine secretion in swine.J Appl Physiol (1985), vol. 62, no. 3, Mar. 1987, pp. 972–77. Pubmed, doi:10.1152/jappl.1987.62.3.972.
White SR, Sands MF, Popovich KJ, Murphy TM, Munoz NM, Blake J, Mack M, Shioya T, Leff AR. Homeostatic regulation of airway smooth muscle tone by catecholamine secretion in swine. J Appl Physiol (1985). 1987 Mar;62(3):972–977.

Published In

J Appl Physiol (1985)

DOI

ISSN

8750-7587

Publication Date

March 1987

Volume

62

Issue

3

Start / End Page

972 / 977

Location

United States

Related Subject Headings

  • Sympathetic Nervous System
  • Swine
  • Respiratory System
  • Respiratory Physiological Phenomena
  • Prostaglandins F
  • Physiology
  • Norepinephrine
  • Muscle, Smooth
  • Male
  • Kinetics