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Defective release of tissue plasminogen activator in systemic and cutaneous vasculitis.

Publication ,  Journal Article
Jordan, JM; Allen, NB; Pizzo, SV
Published in: Am J Med
March 1987

The fibrinolytic system in a group of 23 patients with vasculitis and 10 patients with the cutaneous vasculitis atrophie blanche were studied. These patients were found to have markedly suppressed release of vascular tissue plasminogen activator (t-PA) stores whether the disease was active or in remission. The control group had releasable t-PA levels of 0.70 +/- 0.10 IU/ml of plasma. Levels of releasable t-PA in the patient population were 0.09 +/- 0.03 IU/ml for those with active vasculitis (p less than 0.0001 compared with the control group by the Student t test), 0.23 +/- 0.12 IU/ml for those with inactive vasculitis (p less than 0.001), and 0.03 +/- 0.01 IU/ml for those with atrophie blanche (p less than 0.0001). It is concluded that there is a generalized defect in plasminogen activator in a variety of vasculitides. Such a defect may contribute to the pathogenesis of lesions as well as the thromboembolic disease that may be observed in these patients.

Duke Scholars

Published In

Am J Med

DOI

ISSN

0002-9343

Publication Date

March 1987

Volume

82

Issue

3

Start / End Page

397 / 400

Location

United States

Related Subject Headings

  • Vasculitis
  • Tissue Plasminogen Activator
  • Skin Diseases
  • Skin
  • Middle Aged
  • Male
  • Humans
  • General & Internal Medicine
  • Female
  • Atrophy
 

Citation

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MLA
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Jordan, J. M., Allen, N. B., & Pizzo, S. V. (1987). Defective release of tissue plasminogen activator in systemic and cutaneous vasculitis. Am J Med, 82(3), 397–400. https://doi.org/10.1016/0002-9343(87)90436-0
Jordan, J. M., N. B. Allen, and S. V. Pizzo. “Defective release of tissue plasminogen activator in systemic and cutaneous vasculitis.Am J Med 82, no. 3 (March 1987): 397–400. https://doi.org/10.1016/0002-9343(87)90436-0.
Jordan JM, Allen NB, Pizzo SV. Defective release of tissue plasminogen activator in systemic and cutaneous vasculitis. Am J Med. 1987 Mar;82(3):397–400.
Jordan, J. M., et al. “Defective release of tissue plasminogen activator in systemic and cutaneous vasculitis.Am J Med, vol. 82, no. 3, Mar. 1987, pp. 397–400. Pubmed, doi:10.1016/0002-9343(87)90436-0.
Jordan JM, Allen NB, Pizzo SV. Defective release of tissue plasminogen activator in systemic and cutaneous vasculitis. Am J Med. 1987 Mar;82(3):397–400.
Journal cover image

Published In

Am J Med

DOI

ISSN

0002-9343

Publication Date

March 1987

Volume

82

Issue

3

Start / End Page

397 / 400

Location

United States

Related Subject Headings

  • Vasculitis
  • Tissue Plasminogen Activator
  • Skin Diseases
  • Skin
  • Middle Aged
  • Male
  • Humans
  • General & Internal Medicine
  • Female
  • Atrophy