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Bullous eruption of systemic lupus erythematosus. Dramatic response to dapsone therapy.

Publication ,  Journal Article
Hall, RP; Lawley, TJ; Smith, HR; Katz, SI
Published in: Ann Intern Med
August 1982

Four patients with systemic lupus erythematosus developed a nonpruritic vesiculobullous eruption that was unresponsive to high-dose systemic corticosteroid therapy. In three patients the eruption was not associated with a flare of systemic disease. Biopsy results showed neutrophilic microabscesses at the dermal papillary tips and perivascular lymphohistiocytic infiltrates. Direct immunofluorescence of normal appearing skin not exposed to the sun was positive in all four patients. Due to the unresponsiveness to corticosteroid therapy and the striking histologic resemblance to dermatitis herpetiformis, each of the patients was treated with dapsone. Within 24 hours each patient had prompt cessation of the appearance of new lesions. Improvement of the eruption did not correlate with improvement of the systemic manifestations of their lupus erythematosus. The rapid response to dapsone therapy suggests that dapsone is useful in treating bullous lesions of systemic lupus erythematosus.

Duke Scholars

Published In

Ann Intern Med

DOI

ISSN

0003-4819

Publication Date

August 1982

Volume

97

Issue

2

Start / End Page

165 / 170

Location

United States

Related Subject Headings

  • Skin Diseases, Vesiculobullous
  • Skin
  • Male
  • Lupus Erythematosus, Systemic
  • Humans
  • General & Internal Medicine
  • Female
  • Dapsone
  • Child
  • Adult
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hall, R. P., Lawley, T. J., Smith, H. R., & Katz, S. I. (1982). Bullous eruption of systemic lupus erythematosus. Dramatic response to dapsone therapy. Ann Intern Med, 97(2), 165–170. https://doi.org/10.7326/0003-4819-97-2-165
Hall, R. P., T. J. Lawley, H. R. Smith, and S. I. Katz. “Bullous eruption of systemic lupus erythematosus. Dramatic response to dapsone therapy.Ann Intern Med 97, no. 2 (August 1982): 165–70. https://doi.org/10.7326/0003-4819-97-2-165.
Hall RP, Lawley TJ, Smith HR, Katz SI. Bullous eruption of systemic lupus erythematosus. Dramatic response to dapsone therapy. Ann Intern Med. 1982 Aug;97(2):165–70.
Hall, R. P., et al. “Bullous eruption of systemic lupus erythematosus. Dramatic response to dapsone therapy.Ann Intern Med, vol. 97, no. 2, Aug. 1982, pp. 165–70. Pubmed, doi:10.7326/0003-4819-97-2-165.
Hall RP, Lawley TJ, Smith HR, Katz SI. Bullous eruption of systemic lupus erythematosus. Dramatic response to dapsone therapy. Ann Intern Med. 1982 Aug;97(2):165–170.

Published In

Ann Intern Med

DOI

ISSN

0003-4819

Publication Date

August 1982

Volume

97

Issue

2

Start / End Page

165 / 170

Location

United States

Related Subject Headings

  • Skin Diseases, Vesiculobullous
  • Skin
  • Male
  • Lupus Erythematosus, Systemic
  • Humans
  • General & Internal Medicine
  • Female
  • Dapsone
  • Child
  • Adult