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IgA-containing immune complexes in patients with psoriatic arthritis.

Publication ,  Journal Article
Hall, RP; Gerber, LH; Lawley, TJ
Published in: Clin Exp Rheumatol
1984

Using a sensitive, specific Raji cell radioimmunoassay we have analyzed the sera of 35 patients with psoriatic arthritis (PsA) for IgA-containing circulating immune complexes. In addition, the 125I-Clq binding assay and the Raji IgG radio-immunoassay were used to measure IgG or IgM containing circulating immune complexes. Twenty-eight of thirty five (80%) patients with PsA were found to have IgA-containing circulating immune complexes. In contrast, only 13 of 35 (37%) had IgG-containing circulating immune complexes detected using the Raji IgG assay and 10 of 33 (33%) had IgG- or IgM-containing immune complexes detected using the 125I-Clq binding assay. There was no significant difference in the frequency, level, or type of immune complexes detected in any of the clinical subtypes. There was however a significant correlation between the level of IgA-containing circulating immune complexes and the severity of the arthritis as determined by linear regression analysis (p less than 0.05). The finding of IgA-containing circulating immune complexes in 80% of patients with psoriatic arthritis as well as the significantly higher levels of these complexes in the patients with more severe arthritis suggests that IgA-containing circulating immune complexes may play a role in the pathogenesis of psoriatic arthritis.

Duke Scholars

Published In

Clin Exp Rheumatol

ISSN

0392-856X

Publication Date

1984

Volume

2

Issue

3

Start / End Page

221 / 225

Location

Italy

Related Subject Headings

  • Radioimmunoassay
  • Psoriasis
  • Middle Aged
  • Male
  • Immunoglobulin A
  • Humans
  • Female
  • Arthritis & Rheumatology
  • Arthritis
  • Antigen-Antibody Complex
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hall, R. P., Gerber, L. H., & Lawley, T. J. (1984). IgA-containing immune complexes in patients with psoriatic arthritis. Clin Exp Rheumatol, 2(3), 221–225.
Hall, R. P., L. H. Gerber, and T. J. Lawley. “IgA-containing immune complexes in patients with psoriatic arthritis.Clin Exp Rheumatol 2, no. 3 (1984): 221–25.
Hall RP, Gerber LH, Lawley TJ. IgA-containing immune complexes in patients with psoriatic arthritis. Clin Exp Rheumatol. 1984;2(3):221–5.
Hall, R. P., et al. “IgA-containing immune complexes in patients with psoriatic arthritis.Clin Exp Rheumatol, vol. 2, no. 3, 1984, pp. 221–25.
Hall RP, Gerber LH, Lawley TJ. IgA-containing immune complexes in patients with psoriatic arthritis. Clin Exp Rheumatol. 1984;2(3):221–225.

Published In

Clin Exp Rheumatol

ISSN

0392-856X

Publication Date

1984

Volume

2

Issue

3

Start / End Page

221 / 225

Location

Italy

Related Subject Headings

  • Radioimmunoassay
  • Psoriasis
  • Middle Aged
  • Male
  • Immunoglobulin A
  • Humans
  • Female
  • Arthritis & Rheumatology
  • Arthritis
  • Antigen-Antibody Complex