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Scanning electron microscopic study of the airways in normal children and in patients with cystic fibrosis and other lung diseases.

Publication ,  Journal Article
Simel, DL; Mastin, JP; Pratt, PC; Wisseman, CL; Shelburne, JD; Spock, A; Ingram, P
Published in: Pediatr Pathol
1984
Published version (DOI) Link to item

Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) were used to examine pulmonary tissue from 9 patients with cystic fibrosis (CF), 12 patients with diseases other than CF, and from two surgically resected specimens with no known airways disease. A region of the human airways, the transition zone, was observed between the end of the terminal bronchiole and the type II alveolar cell lining of the respiratory bronchioles. This region was lined predominantly by nonciliated bronchiolar (NCB) cells. Patients with CF exhibited indistinct transition zones, epidermoid metaplasia, large dilated bronchial glands, copious surface mucus, alveolar destruction, and unusual microvilli; no single lesion specific for cystic fibrosis was identified.

Duke Scholars

David Lee Simel
Author David Lee Simel Medicine, General Internal Medicine
John Daniel Shelburne
Author John Daniel Shelburne Pathology

Published In

Pediatr Pathol

DOI

10.3109/15513818409041187

ISSN

0277-0938

Publication Date

1984

Volume

2

Issue

1

Start / End Page

47 / 64

Location

United States

Related Subject Headings

  • Pulmonary Alveoli
  • Mucus
  • Microvilli
  • Microscopy, Electron, Scanning
  • Male
  • Lung Diseases
  • Lung
  • Infant
  • Humans
  • Female
 

Citation

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ICMJE
MLA
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Simel, D. L., Mastin, J. P., Pratt, P. C., Wisseman, C. L., Shelburne, J. D., Spock, A., & Ingram, P. (1984). Scanning electron microscopic study of the airways in normal children and in patients with cystic fibrosis and other lung diseases. Pediatr Pathol, 2(1), 47–64. https://doi.org/10.3109/15513818409041187
Simel, D. L., J. P. Mastin, P. C. Pratt, C. L. Wisseman, J. D. Shelburne, A. Spock, and P. Ingram. “Scanning electron microscopic study of the airways in normal children and in patients with cystic fibrosis and other lung diseases.” Pediatr Pathol 2, no. 1 (1984): 47–64. https://doi.org/10.3109/15513818409041187.
Simel DL, Mastin JP, Pratt PC, Wisseman CL, Shelburne JD, Spock A, et al. Scanning electron microscopic study of the airways in normal children and in patients with cystic fibrosis and other lung diseases. Pediatr Pathol. 1984;2(1):47–64.
Simel, D. L., et al. “Scanning electron microscopic study of the airways in normal children and in patients with cystic fibrosis and other lung diseases.” Pediatr Pathol, vol. 2, no. 1, 1984, pp. 47–64. Pubmed, doi:10.3109/15513818409041187.
Simel DL, Mastin JP, Pratt PC, Wisseman CL, Shelburne JD, Spock A, Ingram P. Scanning electron microscopic study of the airways in normal children and in patients with cystic fibrosis and other lung diseases. Pediatr Pathol. 1984;2(1):47–64.

Published In

Pediatr Pathol

DOI

10.3109/15513818409041187

ISSN

0277-0938

Publication Date

1984

Volume

2

Issue

1

Start / End Page

47 / 64

Location

United States

Related Subject Headings

  • Pulmonary Alveoli
  • Mucus
  • Microvilli
  • Microscopy, Electron, Scanning
  • Male
  • Lung Diseases
  • Lung
  • Infant
  • Humans
  • Female