IFN-gamma production in response to neuropathogenic Cas-Br-M murine leukemia virus infection.
T cell-mediated production of IFN-gamma followed infection of adult, but not neonatal NFS/N mice with Cas-Br-M murine leukemia virus (Cas). The IFN-gamma response was associated with the appearance of CTL specific for Cas and with age-dependent resistance to neurologic disease. While both immune responses were mediated by a CD8-enriched population of T cells, IFN-gamma did not play a role in the activation of the Cas-specific CTL response. However, when given exogenously, IFN-gamma delayed the onset and reduced the incidence of Cas-induced neurologic disease. These data suggest that the IFN-gamma response to Cas infection may be an important host defense mechanism whose effects on virus replication and neurologic disease expression are independent of its effect on Cas-specific CTL.
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Related Subject Headings
- Virus Replication
- Virology
- Tumor Virus Infections
- T-Lymphocytes, Cytotoxic
- T-Lymphocyte Subsets
- Spleen
- Retroviridae Infections
- Polymerase Chain Reaction
- Nervous System Diseases
- Molecular Sequence Data
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Virus Replication
- Virology
- Tumor Virus Infections
- T-Lymphocytes, Cytotoxic
- T-Lymphocyte Subsets
- Spleen
- Retroviridae Infections
- Polymerase Chain Reaction
- Nervous System Diseases
- Molecular Sequence Data