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Abstinence-induced changes in self-report craving correlate with event-related FMRI responses to smoking cues.

Publication ,  Journal Article
McClernon, FJ; Hiott, FB; Huettel, SA; Rose, JE
Published in: Neuropsychopharmacology
October 2005

Drug cues have been shown to activate brain regions involved in attention, motivation, and reward in addicted users. However, as studies have typically measured responses in only one state (ie drug abstinence), it is unclear whether observed activations represent amplification by abstinence or stable responses. Thus, the present study was designed to evaluate the stability of event-related responses to visual drug cues in dependent smokers (n=13) using event-related functional magnetic resonance imaging measures. Imaging was conducted following smoking as usual and following overnight abstinence, and self-reported craving measures were obtained before, during, and after scanning. Analysis of hemodynamic response (HDR) amplitudes in each of 13 regions of interest revealed larger responses to smoking compared to control cues in ventral anterior cingulate gyrus (vACG) and superior frontal gyrus. Responses to smoking cues in these and all other regions revealed no effects of abstinence/satiety, thus supporting the notion that cue-elicited brain responses are relatively stable. However, while the abstinence manipulation did not alter group-level responses to smoking cues, at the individual level, abstinence-induced changes in craving (abstinence minus satiety) were positively correlated with changes in HDR amplitude to smoking cues in frontal regions including left inferior frontal gyrus, left vACG, and bilateral middle frontal gyrus. These results suggest that brain responses to smoking cues, while relatively stable at the group level following short-term abstinence, may be modulated by individual differences in craving in response to abstinence-particularly in regions subserving attention and motivation.

Duke Scholars

Published In

Neuropsychopharmacology

DOI

ISSN

0893-133X

Publication Date

October 2005

Volume

30

Issue

10

Start / End Page

1940 / 1947

Location

England

Related Subject Headings

  • Surveys and Questionnaires
  • Smoking Cessation
  • Smoking
  • Psychiatry
  • Photic Stimulation
  • Oxygen
  • Magnetic Resonance Imaging
  • Humans
  • Gyrus Cinguli
  • Functional Laterality
 

Citation

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McClernon, F. J., Hiott, F. B., Huettel, S. A., & Rose, J. E. (2005). Abstinence-induced changes in self-report craving correlate with event-related FMRI responses to smoking cues. Neuropsychopharmacology, 30(10), 1940–1947. https://doi.org/10.1038/sj.npp.1300780
McClernon, F Joseph, F Berry Hiott, Scott A. Huettel, and Jed E. Rose. “Abstinence-induced changes in self-report craving correlate with event-related FMRI responses to smoking cues.Neuropsychopharmacology 30, no. 10 (October 2005): 1940–47. https://doi.org/10.1038/sj.npp.1300780.
McClernon FJ, Hiott FB, Huettel SA, Rose JE. Abstinence-induced changes in self-report craving correlate with event-related FMRI responses to smoking cues. Neuropsychopharmacology. 2005 Oct;30(10):1940–7.
McClernon, F. Joseph, et al. “Abstinence-induced changes in self-report craving correlate with event-related FMRI responses to smoking cues.Neuropsychopharmacology, vol. 30, no. 10, Oct. 2005, pp. 1940–47. Pubmed, doi:10.1038/sj.npp.1300780.
McClernon FJ, Hiott FB, Huettel SA, Rose JE. Abstinence-induced changes in self-report craving correlate with event-related FMRI responses to smoking cues. Neuropsychopharmacology. 2005 Oct;30(10):1940–1947.
Journal cover image

Published In

Neuropsychopharmacology

DOI

ISSN

0893-133X

Publication Date

October 2005

Volume

30

Issue

10

Start / End Page

1940 / 1947

Location

England

Related Subject Headings

  • Surveys and Questionnaires
  • Smoking Cessation
  • Smoking
  • Psychiatry
  • Photic Stimulation
  • Oxygen
  • Magnetic Resonance Imaging
  • Humans
  • Gyrus Cinguli
  • Functional Laterality