Thickness control in the living cornea

The mechanisms by which the normal cornea maintains its thickness and hence its transparency in vivo are elucidated by an unsteady-state description of corneal mass transport. All modes of transport, diffusion and convection of solute, hydraulic and osmotic flow of solvent, and active transport by the corneal cells themselves, are of necessity included in the analysis. An a priori calculation of corneal dynamics based on this model shows good agreement with experiment. The physiological insights thus gained have clinical implications as well, and a number of these are mentioned briefly

Duke Scholars

Author Morton Friedman Biomedical Engineering