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Diagnostic blood flow monitoring during therapeutic interventions using color Doppler optical coherence tomography

Publication ,  Journal Article
Yazdanfar, S; Kulkarni, MD; Wong, RCK; Sivak, MV; Willis, J; Barton, JK; Welch, AJ; Izatt, JA
Published in: Proceedings of SPIE - The International Society for Optical Engineering
December 1, 1998

A recently developed modality for blood flow measurement holds high promise in the management of bleeding ulcers. Color Doppler optical coherence tomography (CDOCT) uses low-coherence interferometry and digital signal processing to obtain precise localization of tissue microstructure simultaneous with bi-directional quantitation of blood flow. We discuss CDOCT as a diagnostic tool in the management of bleeding gastrointestinal lesions. Common treatments for bleeding ulcers include local injection of a vasoconstrictor, coagulation of blood via thermal contact or laser treatment, and necrosis of surrounding tissue with a sclerosant. We implemented these procedures in a rat dorsal skin flap model, and acquired CDOCT images before and after treatment. In these studies, CDOCT succeeded in identifying cessation of flow before it could be determined visually. Hence, we demonstrate the diagnostic capabilities of CDOCT in the regulation of bleeding in micron-scale vessels.

Duke Scholars

Published In

Proceedings of SPIE - The International Society for Optical Engineering

DOI

ISSN

0277-786X

Publication Date

December 1, 1998

Volume

3251

Start / End Page

126 / 132

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4009 Electronics, sensors and digital hardware
  • 4006 Communications engineering
 

Citation

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Yazdanfar, S., Kulkarni, M. D., Wong, R. C. K., Sivak, M. V., Willis, J., Barton, J. K., … Izatt, J. A. (1998). Diagnostic blood flow monitoring during therapeutic interventions using color Doppler optical coherence tomography. Proceedings of SPIE - The International Society for Optical Engineering, 3251, 126–132. https://doi.org/10.1117/12.306046
Yazdanfar, S., M. D. Kulkarni, R. C. K. Wong, M. V. Sivak, J. Willis, J. K. Barton, A. J. Welch, and J. A. Izatt. “Diagnostic blood flow monitoring during therapeutic interventions using color Doppler optical coherence tomography.” Proceedings of SPIE - The International Society for Optical Engineering 3251 (December 1, 1998): 126–32. https://doi.org/10.1117/12.306046.
Yazdanfar S, Kulkarni MD, Wong RCK, Sivak MV, Willis J, Barton JK, et al. Diagnostic blood flow monitoring during therapeutic interventions using color Doppler optical coherence tomography. Proceedings of SPIE - The International Society for Optical Engineering. 1998 Dec 1;3251:126–32.
Yazdanfar, S., et al. “Diagnostic blood flow monitoring during therapeutic interventions using color Doppler optical coherence tomography.” Proceedings of SPIE - The International Society for Optical Engineering, vol. 3251, Dec. 1998, pp. 126–32. Scopus, doi:10.1117/12.306046.
Yazdanfar S, Kulkarni MD, Wong RCK, Sivak MV, Willis J, Barton JK, Welch AJ, Izatt JA. Diagnostic blood flow monitoring during therapeutic interventions using color Doppler optical coherence tomography. Proceedings of SPIE - The International Society for Optical Engineering. 1998 Dec 1;3251:126–132.

Published In

Proceedings of SPIE - The International Society for Optical Engineering

DOI

ISSN

0277-786X

Publication Date

December 1, 1998

Volume

3251

Start / End Page

126 / 132

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4009 Electronics, sensors and digital hardware
  • 4006 Communications engineering