Skip to main content

Fibre-optic-based fluoroimmunosensors

Publication ,  Journal Article
Sepaniak, MJ; Vo Dinh, T
Published in: Philos. Trans. R. Soc. A, Phys. Sci. Eng. (UK)
1990

Remote sensing of chemicals can be performed using fibre optic chemical sensors that use immunochemical reagent phases. Exploiting the specificity of antibody-antigen interactions and the sensitivity of laser-excited fluorimetry, highly selective measurement of ultra-trace levels of chemicals can be performed remotely and in situ via fluoroimmunoassay techniques. In this work, heterogeneous assay protocols using immunobeads are implemented. A passive sensor that samples the analyte by diffusion through a permeable membrane and is capable of a single analysis is described and used for the measurement of a naturally fluorescent compound. Subsequently, a regenerable sensor that can perform assay procedures in a repetitive fashion is described and characterized. The versatility of this sensor for performing remote measurements using a variety of established fluoroimmunoassay methodologies is discussed

Duke Scholars

Published In

Philos. Trans. R. Soc. A, Phys. Sci. Eng. (UK)

Publication Date

1990

Volume

333

Issue

1628

Start / End Page

85 / 92
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Sepaniak, M. J., & Vo Dinh, T. (1990). Fibre-optic-based fluoroimmunosensors. Philos. Trans. R. Soc. A, Phys. Sci. Eng. (UK), 333(1628), 85–92.
Sepaniak, M. J., and T. Vo Dinh. “Fibre-optic-based fluoroimmunosensors.” Philos. Trans. R. Soc. A, Phys. Sci. Eng. (UK) 333, no. 1628 (1990): 85–92.
Sepaniak MJ, Vo Dinh T. Fibre-optic-based fluoroimmunosensors. Philos Trans R Soc A, Phys Sci Eng (UK). 1990;333(1628):85–92.
Sepaniak, M. J., and T. Vo Dinh. “Fibre-optic-based fluoroimmunosensors.” Philos. Trans. R. Soc. A, Phys. Sci. Eng. (UK), vol. 333, no. 1628, 1990, pp. 85–92.
Sepaniak MJ, Vo Dinh T. Fibre-optic-based fluoroimmunosensors. Philos Trans R Soc A, Phys Sci Eng (UK). 1990;333(1628):85–92.

Published In

Philos. Trans. R. Soc. A, Phys. Sci. Eng. (UK)

Publication Date

1990

Volume

333

Issue

1628

Start / End Page

85 / 92