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Development of a portable Raman spectrometer for medical diagnostics

Publication ,  Journal Article
Cullum, BM; Mobley, J; Stokes, DL; Allain, LR; Stratis, DN; Wintenberg, AL; Maples, B; Vo-Dinh, T
Published in: Proceedings of SPIE - The International Society for Optical Engineering
January 1, 2002
Published version (DOI)

This paper describes a self-contained, portable Raman instrument that has been developed for biomedical analyses. The instrument consists of a 785-nm diode laser for excitation, an acousto-optic tunable filter (AOTF) for wavelength discrimination, and an avalanche photodiode for detection. The primary component of this system is the AOTF and it has been selected based on its spectral range along with its high resolution, ∼7.5 cm-1. Software has been developed in house in the programming language of C for controlling the instrument (i.e. the AOTF frequency, the signal acquisition, etc.). Evaluation of this instrument has been performed by analyzing several standard samples and comparing their spectra to spectra acquired using a conventional laboratory system. In addition to system evaluation, this paper will also discuss potential applications of this instrument to multiplexed genechip types of analyses. © 2002 SPIE · 0277-786X/02/$15.00.

Duke Scholars

Tuan Vo-Dinh
Author Tuan Vo-Dinh Biomedical Engineering

Published In

Proceedings of SPIE - The International Society for Optical Engineering

DOI

10.1117/12.466637

ISSN

0277-786X

Publication Date

January 1, 2002

Volume

4615

Start / End Page

82 / 90

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4009 Electronics, sensors and digital hardware
  • 4006 Communications engineering
 

Citation

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Cullum, B. M., Mobley, J., Stokes, D. L., Allain, L. R., Stratis, D. N., Wintenberg, A. L., … Vo-Dinh, T. (2002). Development of a portable Raman spectrometer for medical diagnostics. Proceedings of SPIE - The International Society for Optical Engineering, 4615, 82–90. https://doi.org/10.1117/12.466637
Cullum, B. M., J. Mobley, D. L. Stokes, L. R. Allain, D. N. Stratis, A. L. Wintenberg, B. Maples, and T. Vo-Dinh. “Development of a portable Raman spectrometer for medical diagnostics.” Proceedings of SPIE - The International Society for Optical Engineering 4615 (January 1, 2002): 82–90. https://doi.org/10.1117/12.466637.
Cullum BM, Mobley J, Stokes DL, Allain LR, Stratis DN, Wintenberg AL, et al. Development of a portable Raman spectrometer for medical diagnostics. Proceedings of SPIE - The International Society for Optical Engineering. 2002 Jan 1;4615:82–90.
Cullum, B. M., et al. “Development of a portable Raman spectrometer for medical diagnostics.” Proceedings of SPIE - The International Society for Optical Engineering, vol. 4615, Jan. 2002, pp. 82–90. Scopus, doi:10.1117/12.466637.
Cullum BM, Mobley J, Stokes DL, Allain LR, Stratis DN, Wintenberg AL, Maples B, Vo-Dinh T. Development of a portable Raman spectrometer for medical diagnostics. Proceedings of SPIE - The International Society for Optical Engineering. 2002 Jan 1;4615:82–90.

Published In

Proceedings of SPIE - The International Society for Optical Engineering

DOI

10.1117/12.466637

ISSN

0277-786X

Publication Date

January 1, 2002

Volume

4615

Start / End Page

82 / 90

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4009 Electronics, sensors and digital hardware
  • 4006 Communications engineering