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Phase-resolved fiber-optics fluoroimmunosensor

Publication ,  Journal Article
Vo-Dinh, T; Nolan, T; Cheng, YF; Sepaniak, MJ; Alarie, JP
Published in: Applied Spectroscopy
January 1, 1990

This paper describes the development and application of a phase-resolved fiber-optics fluoroimmunosensor (PR-FIS), which combines the biochemical specificity of antigen-antibody reaction, the high sensitivity of laser excitation, the versatility of fiber-optics sensors, and the selectivity of phase-resolved detection. The PR-FIS device can differentiate benzo(a)pyrene and benzo(a)pyrene tetrol, a DNA-adduct product of the carcinogen benzo(a)pyrene. Benzo(a)pyrene tetrol can be detected at femtomole levels in the presence of an amount of interfacing benzo(a)pyrene that is 50-fold more concentrated.

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Published In

Applied Spectroscopy

DOI

ISSN

0003-7028

Publication Date

January 1, 1990

Volume

44

Issue

1

Start / End Page

128 / 132

Related Subject Headings

  • Analytical Chemistry
  • 0913 Mechanical Engineering
  • 0306 Physical Chemistry (incl. Structural)
  • 0301 Analytical Chemistry
 

Citation

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Vo-Dinh, T., Nolan, T., Cheng, Y. F., Sepaniak, M. J., & Alarie, J. P. (1990). Phase-resolved fiber-optics fluoroimmunosensor. Applied Spectroscopy, 44(1), 128–132. https://doi.org/10.1366/0003702904085859
Vo-Dinh, T., T. Nolan, Y. F. Cheng, M. J. Sepaniak, and J. P. Alarie. “Phase-resolved fiber-optics fluoroimmunosensor.” Applied Spectroscopy 44, no. 1 (January 1, 1990): 128–32. https://doi.org/10.1366/0003702904085859.
Vo-Dinh T, Nolan T, Cheng YF, Sepaniak MJ, Alarie JP. Phase-resolved fiber-optics fluoroimmunosensor. Applied Spectroscopy. 1990 Jan 1;44(1):128–32.
Vo-Dinh, T., et al. “Phase-resolved fiber-optics fluoroimmunosensor.” Applied Spectroscopy, vol. 44, no. 1, Jan. 1990, pp. 128–32. Scopus, doi:10.1366/0003702904085859.
Vo-Dinh T, Nolan T, Cheng YF, Sepaniak MJ, Alarie JP. Phase-resolved fiber-optics fluoroimmunosensor. Applied Spectroscopy. 1990 Jan 1;44(1):128–132.
Journal cover image

Published In

Applied Spectroscopy

DOI

ISSN

0003-7028

Publication Date

January 1, 1990

Volume

44

Issue

1

Start / End Page

128 / 132

Related Subject Headings

  • Analytical Chemistry
  • 0913 Mechanical Engineering
  • 0306 Physical Chemistry (incl. Structural)
  • 0301 Analytical Chemistry