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Surface-enhanced Raman scattering for medical diagnostics and biological imaging

Publication ,  Journal Article
Vo-Dinh, T; Yan, F; Wabuyele, MB
Published in: Journal of Raman Spectroscopy
January 1, 2005

We present recent development and applications of a surface-enhanced Raman scattering (SERS) technology for use in medical diagnostics and biological imaging. For medical diagnostics, we use Raman-active dye-labeled DNA gene probes and nanostructured metallic substrates as SERS-active platforms. The surface-enhanced Raman gene probes can be used to detect DNA biotargets (e.g. gene sequences, bacteria and viral DNA) via hybridization to DNA sequences complementary to these probes. The SERS gene probes eliminate the need for radioactive labels and have great potential to provide both sensitivity, selectivity and label multiplexing for DNA sequencing and clinical assays. We also describe a hyperspectral surface-enhanced Raman imaging (HSERI) system that combines imaging capabilities with SERS detection to identify cellular components with high spatial and temporal resolution. The HSERI system's application to biological imaging is demonstrated using Raman dye-labeled silver nanoparticles in cellular systems. Copyright © 2005 John Wiley & Sons, Ltd.

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Published In

Journal of Raman Spectroscopy

DOI

ISSN

0377-0486

Publication Date

January 1, 2005

Volume

36

Issue

6-7

Start / End Page

640 / 647

Related Subject Headings

  • Chemical Physics
  • 5104 Condensed matter physics
  • 3406 Physical chemistry
  • 3402 Inorganic chemistry
  • 0913 Mechanical Engineering
  • 0306 Physical Chemistry (incl. Structural)
  • 0204 Condensed Matter Physics
 

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Vo-Dinh, T., Yan, F., & Wabuyele, M. B. (2005). Surface-enhanced Raman scattering for medical diagnostics and biological imaging. Journal of Raman Spectroscopy, 36(6–7), 640–647. https://doi.org/10.1002/jrs.1348
Vo-Dinh, T., F. Yan, and M. B. Wabuyele. “Surface-enhanced Raman scattering for medical diagnostics and biological imaging.” Journal of Raman Spectroscopy 36, no. 6–7 (January 1, 2005): 640–47. https://doi.org/10.1002/jrs.1348.
Vo-Dinh T, Yan F, Wabuyele MB. Surface-enhanced Raman scattering for medical diagnostics and biological imaging. Journal of Raman Spectroscopy. 2005 Jan 1;36(6–7):640–7.
Vo-Dinh, T., et al. “Surface-enhanced Raman scattering for medical diagnostics and biological imaging.” Journal of Raman Spectroscopy, vol. 36, no. 6–7, Jan. 2005, pp. 640–47. Scopus, doi:10.1002/jrs.1348.
Vo-Dinh T, Yan F, Wabuyele MB. Surface-enhanced Raman scattering for medical diagnostics and biological imaging. Journal of Raman Spectroscopy. 2005 Jan 1;36(6–7):640–647.
Journal cover image

Published In

Journal of Raman Spectroscopy

DOI

ISSN

0377-0486

Publication Date

January 1, 2005

Volume

36

Issue

6-7

Start / End Page

640 / 647

Related Subject Headings

  • Chemical Physics
  • 5104 Condensed matter physics
  • 3406 Physical chemistry
  • 3402 Inorganic chemistry
  • 0913 Mechanical Engineering
  • 0306 Physical Chemistry (incl. Structural)
  • 0204 Condensed Matter Physics