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An AOTF-based dual-modality hyperspectral imaging system (DMHSI) capable of simultaneous fluorescence and reflectance imaging.

Publication ,  Journal Article
Martin, ME; Wabuyele, M; Panjehpour, M; Overholt, B; DeNovo, R; Kennel, S; Cunningham, G; Vo-Dinh, T
Published in: Medical engineering & physics
March 2006

An acousto-optic tunable filter (AOTF)-based system for dual-modality hyperspectral imaging (DMHSI) has been developed for use in characterization of normal and malignant mouse tissue. The system consists of a laser, endoscope, AOTF, and two cameras coupled with optics and electronics. Initial results show that the system can delineate normal and malignant mouse tissues real-time. The analysis shows that malignant tissues consistently exhibit less fluorescent intensity in the wavelength band from 440 to 540 nm with a peak intensity of around 490 nm. The analysis also shows key spectroscopic differences between normal and malignant tissues. Further, these results are compared to real-time spectroscopic data and show good correlation.

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Published In

Medical engineering & physics

DOI

EISSN

1873-4030

ISSN

1350-4533

Publication Date

March 2006

Volume

28

Issue

2

Start / End Page

149 / 155

Related Subject Headings

  • Systems Integration
  • Spectrometry, Fluorescence
  • Photometry
  • Neoplasms
  • Mice
  • Lasers
  • Image Interpretation, Computer-Assisted
  • Equipment Failure Analysis
  • Equipment Design
  • Endoscopes
 

Citation

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Martin, M. E., Wabuyele, M., Panjehpour, M., Overholt, B., DeNovo, R., Kennel, S., … Vo-Dinh, T. (2006). An AOTF-based dual-modality hyperspectral imaging system (DMHSI) capable of simultaneous fluorescence and reflectance imaging. Medical Engineering & Physics, 28(2), 149–155. https://doi.org/10.1016/j.medengphy.2005.04.022
Martin, Matt E., Musundi Wabuyele, Masoud Panjehpour, Bergein Overholt, Robert DeNovo, Steve Kennel, Glenn Cunningham, and Tuan Vo-Dinh. “An AOTF-based dual-modality hyperspectral imaging system (DMHSI) capable of simultaneous fluorescence and reflectance imaging.Medical Engineering & Physics 28, no. 2 (March 2006): 149–55. https://doi.org/10.1016/j.medengphy.2005.04.022.
Martin ME, Wabuyele M, Panjehpour M, Overholt B, DeNovo R, Kennel S, et al. An AOTF-based dual-modality hyperspectral imaging system (DMHSI) capable of simultaneous fluorescence and reflectance imaging. Medical engineering & physics. 2006 Mar;28(2):149–55.
Martin, Matt E., et al. “An AOTF-based dual-modality hyperspectral imaging system (DMHSI) capable of simultaneous fluorescence and reflectance imaging.Medical Engineering & Physics, vol. 28, no. 2, Mar. 2006, pp. 149–55. Epmc, doi:10.1016/j.medengphy.2005.04.022.
Martin ME, Wabuyele M, Panjehpour M, Overholt B, DeNovo R, Kennel S, Cunningham G, Vo-Dinh T. An AOTF-based dual-modality hyperspectral imaging system (DMHSI) capable of simultaneous fluorescence and reflectance imaging. Medical engineering & physics. 2006 Mar;28(2):149–155.
Journal cover image

Published In

Medical engineering & physics

DOI

EISSN

1873-4030

ISSN

1350-4533

Publication Date

March 2006

Volume

28

Issue

2

Start / End Page

149 / 155

Related Subject Headings

  • Systems Integration
  • Spectrometry, Fluorescence
  • Photometry
  • Neoplasms
  • Mice
  • Lasers
  • Image Interpretation, Computer-Assisted
  • Equipment Failure Analysis
  • Equipment Design
  • Endoscopes