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Relating radiation-induced regional lung injury to changes in pulmonary function tests.

Publication ,  Journal Article
Fan, M; Marks, LB; Lind, P; Hollis, D; Woel, RT; Bentel, GG; Anscher, MS; Shafman, TD; Coleman, RE; Jaszczak, RJ; Munley, MT
Published in: Int J Radiat Oncol Biol Phys
October 1, 2001

PURPOSE: To determine whether the sum of radiotherapy (RT)-induced reductions in regional lung perfusion is quantitatively related to changes in global lung function as assessed by reductions in pulmonary function tests (PFTs). METHODS AND MATERIALS: Two hundred seven patients (70% with lung cancer) who received incidental partial lung irradiation underwent PFTs (forced expiratory volume in 1 s and diffusion capacity for carbon monoxide) before and repeatedly after RT as part of a prospective clinical study. Regional lung function was serially assessed before and after RT by single photon emission computed tomography perfusion scans. Of these, 53 patients had 105 post-RT evaluations of changes in both regional perfusion and PFTs, were without evidence of intrathoracic disease recurrence that might influence regional perfusion and PFT findings, and were not taking steroids. The summation of the regional functional perfusion changes were compared with changes in PFTs using linear regression analysis. RESULTS: Follow-up ranged from 3 to 86 months (median 19). Overall, a significant correlation was found between the sum of changes in regional perfusion and the changes in the PFTs (p = 0.002-0.24, depending on the particular PFT index). However, the correlation coefficients were small (r = 0.16-0.41). CONCLUSIONS: A statistically significant correlation was found between RT-induced changes in regional function (i.e., perfusion) and global function (i.e., PFTs). However, the correlation coefficients are low, making it difficult to relate changes in perfusion to changes in the PFT results. Thus, with our current techniques, the prediction of changes in perfusion alone does not appear to be sufficient to predict the changes in PFTs accurately. Additional studies to clarify the relationship between regional and global lung injury are needed.

Duke Scholars

Published In

Int J Radiat Oncol Biol Phys

DOI

ISSN

0360-3016

Publication Date

October 1, 2001

Volume

51

Issue

2

Start / End Page

311 / 317

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Tomography, Emission-Computed, Single-Photon
  • Radiotherapy Dosage
  • Radiation Injuries
  • Prospective Studies
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Lymphoma
  • Lung Neoplasms
 

Citation

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MLA
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Fan, M., Marks, L. B., Lind, P., Hollis, D., Woel, R. T., Bentel, G. G., … Munley, M. T. (2001). Relating radiation-induced regional lung injury to changes in pulmonary function tests. Int J Radiat Oncol Biol Phys, 51(2), 311–317. https://doi.org/10.1016/s0360-3016(01)01619-4
Fan, M., L. B. Marks, P. Lind, D. Hollis, R. T. Woel, G. G. Bentel, M. S. Anscher, et al. “Relating radiation-induced regional lung injury to changes in pulmonary function tests.Int J Radiat Oncol Biol Phys 51, no. 2 (October 1, 2001): 311–17. https://doi.org/10.1016/s0360-3016(01)01619-4.
Fan M, Marks LB, Lind P, Hollis D, Woel RT, Bentel GG, et al. Relating radiation-induced regional lung injury to changes in pulmonary function tests. Int J Radiat Oncol Biol Phys. 2001 Oct 1;51(2):311–7.
Fan, M., et al. “Relating radiation-induced regional lung injury to changes in pulmonary function tests.Int J Radiat Oncol Biol Phys, vol. 51, no. 2, Oct. 2001, pp. 311–17. Pubmed, doi:10.1016/s0360-3016(01)01619-4.
Fan M, Marks LB, Lind P, Hollis D, Woel RT, Bentel GG, Anscher MS, Shafman TD, Coleman RE, Jaszczak RJ, Munley MT. Relating radiation-induced regional lung injury to changes in pulmonary function tests. Int J Radiat Oncol Biol Phys. 2001 Oct 1;51(2):311–317.
Journal cover image

Published In

Int J Radiat Oncol Biol Phys

DOI

ISSN

0360-3016

Publication Date

October 1, 2001

Volume

51

Issue

2

Start / End Page

311 / 317

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Tomography, Emission-Computed, Single-Photon
  • Radiotherapy Dosage
  • Radiation Injuries
  • Prospective Studies
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Lymphoma
  • Lung Neoplasms