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Design considerations and initial performance of a 1.2 cm2 beta imaging intra-operative probe

Publication ,  Journal Article
Tornai, MP; MacDonald, LR; Levin, CS; Siegel, S; Hoffman, EJ
Published in: IEEE Transactions on Nuclear Science
December 1, 1996

A novel small area beta (β±) detector is under development for nuclear emission imaging of surgically exposed, radiolabeled tumor beds. The imaging device front-end consists of a 0.5 mm thick by 1.25 cm diameter CaF2(Eu) scintillator disk coupled to a rigid bundle of 2 mm diameter double clad optical fibers through a polystyrene light diffuser. The detector area (1.2 cm2) was determined by the requirement of introducing the probe into small cavities, e.g. during neuro-surgical lesion resection, but large enough to produce images of clinical significance. Flexible back-end optical fibers (1.9 m long) were coupled to the front-end components allowing ∼75 photoelectrons to be detected for mean beta energies of 250 keV, indicating that sufficient signal can be obtained with clinical beta emitters (e.g. 18F, 131I). The long flexible fibers guide the scintillation light to a Philips XP1700 series, fiber optic faceplate, Multi-Channel PMT. The parallel MC-PMT outputs arc fed into a variable gain, charge divider network and an i-V pre-amplifier/line driver network, whose resulting four outpuls are digitized and histogrammed with standard Anger positioning logic. The various components in the imaging chain were evaluated and optimized by both simulations and measurements. Line spread functions measured in the 10.8 mm FOV were 0.50 mm ±0.038 mm and 0.55 mm ±0.065 mm FWHM in X and Y, respectively. A 20% variation in pulse height and minimal variation in spatial resolution was observed. The differential image uniformity was measured to be ±15.6% with ∼150 cts/pixel. Preliminary images show excellent reproduction of phantom activity distributions. © 1996 IEEE.

Duke Scholars

Published In

IEEE Transactions on Nuclear Science

DOI

ISSN

0018-9499

Publication Date

December 1, 1996

Volume

43

Issue

4 PART 1

Start / End Page

2326 / 2335

Related Subject Headings

  • Nuclear & Particles Physics
  • 5106 Nuclear and plasma physics
  • 0903 Biomedical Engineering
  • 0299 Other Physical Sciences
  • 0202 Atomic, Molecular, Nuclear, Particle and Plasma Physics
 

Citation

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MLA
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Tornai, M. P., MacDonald, L. R., Levin, C. S., Siegel, S., & Hoffman, E. J. (1996). Design considerations and initial performance of a 1.2 cm2 beta imaging intra-operative probe. IEEE Transactions on Nuclear Science, 43(4 PART 1), 2326–2335. https://doi.org/10.1109/23.531898
Tornai, M. P., L. R. MacDonald, C. S. Levin, S. Siegel, and E. J. Hoffman. “Design considerations and initial performance of a 1.2 cm2 beta imaging intra-operative probe.” IEEE Transactions on Nuclear Science 43, no. 4 PART 1 (December 1, 1996): 2326–35. https://doi.org/10.1109/23.531898.
Tornai MP, MacDonald LR, Levin CS, Siegel S, Hoffman EJ. Design considerations and initial performance of a 1.2 cm2 beta imaging intra-operative probe. IEEE Transactions on Nuclear Science. 1996 Dec 1;43(4 PART 1):2326–35.
Tornai, M. P., et al. “Design considerations and initial performance of a 1.2 cm2 beta imaging intra-operative probe.” IEEE Transactions on Nuclear Science, vol. 43, no. 4 PART 1, Dec. 1996, pp. 2326–35. Scopus, doi:10.1109/23.531898.
Tornai MP, MacDonald LR, Levin CS, Siegel S, Hoffman EJ. Design considerations and initial performance of a 1.2 cm2 beta imaging intra-operative probe. IEEE Transactions on Nuclear Science. 1996 Dec 1;43(4 PART 1):2326–2335.

Published In

IEEE Transactions on Nuclear Science

DOI

ISSN

0018-9499

Publication Date

December 1, 1996

Volume

43

Issue

4 PART 1

Start / End Page

2326 / 2335

Related Subject Headings

  • Nuclear & Particles Physics
  • 5106 Nuclear and plasma physics
  • 0903 Biomedical Engineering
  • 0299 Other Physical Sciences
  • 0202 Atomic, Molecular, Nuclear, Particle and Plasma Physics