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Quantitative SPECT Brain Imaging: Effects of Attenuation and Detector Response

Publication ,  Journal Article
Gilland, DR; Jaszczak, RJ; Bowsher, JE; Turkington, TG; Liang, Z; Greer, KL; Coleman, RE
Published in: IEEE Transactions on Nuclear Science
January 1, 1993

Two physical factors that substantially degrade quantitative accuracy in SPECT imaging of the brain are attenuation and detector response. In addition to the physical factors, random noise in the reconstructed image can greatly affect the quantitative measurement. The purpose of this work was to implement two reconstruction methods that compensate for attenuation and detector response, a 3D maximum likelihood-EM method (ML) and a filtered backprojection method (FB) with Metz filter and Chang attenuation compensation, and compare the methods in terms of quantitative accuracy and image noise. The methods were tested on simulated data of the 3D Hoffman brain phantom. The simulation imcorporated attenuation and distance-dependent detector response. Bias and standard deviation of reconstructed voxel intensities were measured in the gray and white matter regions. The results with ML showed that in both the gray and white matter regions as the number of iterations increased, bias decreased and standard deviation increased. Similar results were observed with FB as the Metz filter power increased. In both regions, ML had smaller standard deviation than FB for a given bias. Reconstruction times for the ML method have been greatly reduced through efficient coding, limited source support, and by computing attenuation factors only along rays perpendicular to the detector. © 1993 IEEE

Duke Scholars

Published In

IEEE Transactions on Nuclear Science

DOI

EISSN

1558-1578

ISSN

0018-9499

Publication Date

January 1, 1993

Volume

40

Issue

3

Start / End Page

295 / 299

Related Subject Headings

  • Nuclear & Particles Physics
  • 5106 Nuclear and plasma physics
  • 0903 Biomedical Engineering
  • 0299 Other Physical Sciences
  • 0202 Atomic, Molecular, Nuclear, Particle and Plasma Physics
 

Citation

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Gilland, D. R., Jaszczak, R. J., Bowsher, J. E., Turkington, T. G., Liang, Z., Greer, K. L., & Coleman, R. E. (1993). Quantitative SPECT Brain Imaging: Effects of Attenuation and Detector Response. IEEE Transactions on Nuclear Science, 40(3), 295–299. https://doi.org/10.1109/23.221054
Gilland, D. R., R. J. Jaszczak, J. E. Bowsher, T. G. Turkington, Z. Liang, K. L. Greer, and R. E. Coleman. “Quantitative SPECT Brain Imaging: Effects of Attenuation and Detector Response.” IEEE Transactions on Nuclear Science 40, no. 3 (January 1, 1993): 295–99. https://doi.org/10.1109/23.221054.
Gilland DR, Jaszczak RJ, Bowsher JE, Turkington TG, Liang Z, Greer KL, et al. Quantitative SPECT Brain Imaging: Effects of Attenuation and Detector Response. IEEE Transactions on Nuclear Science. 1993 Jan 1;40(3):295–9.
Gilland, D. R., et al. “Quantitative SPECT Brain Imaging: Effects of Attenuation and Detector Response.” IEEE Transactions on Nuclear Science, vol. 40, no. 3, Jan. 1993, pp. 295–99. Scopus, doi:10.1109/23.221054.
Gilland DR, Jaszczak RJ, Bowsher JE, Turkington TG, Liang Z, Greer KL, Coleman RE. Quantitative SPECT Brain Imaging: Effects of Attenuation and Detector Response. IEEE Transactions on Nuclear Science. 1993 Jan 1;40(3):295–299.

Published In

IEEE Transactions on Nuclear Science

DOI

EISSN

1558-1578

ISSN

0018-9499

Publication Date

January 1, 1993

Volume

40

Issue

3

Start / End Page

295 / 299

Related Subject Headings

  • Nuclear & Particles Physics
  • 5106 Nuclear and plasma physics
  • 0903 Biomedical Engineering
  • 0299 Other Physical Sciences
  • 0202 Atomic, Molecular, Nuclear, Particle and Plasma Physics