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Coded aperture Raman spectroscopy for quantitative measurements of ethanol in a tissue phantom

Publication ,  Journal Article
McCain, ST; Gehm, ME; Wang, Y; Pitsianis, NP; Brady, DJ
Published in: Applied Spectroscopy
2006

Coded aperture spectroscopy allows for sources of large etendue to be efficiently coupled into dispersive spectrometers by replacing the traditional input slit with a patterned mask. We describe a coded aperture spectrometer optimized for Raman spectroscopy of diffuse sources, (e.g., tissue). We provide design details of the Raman system, along with quantitative estimation results for ethanol at non-toxic levels in a lipid tissue phantom. With 60 mW of excitation power at 808 nm, leave-one-out and blind cross-validation of partial least squares (PLS) regression models achieve r 2 > 0.98. Leave-one-out cross-validation demonstrates prediction errors of less than or equal 15% at the common legal limit for intoxication (17.4 mmol/L = 0.08% by vol) and the best blind cross-validation achieves less than or equal 12% error at this concentration. © 2006 Society for Applied Spectroscopy.

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Published In

Applied Spectroscopy

DOI

Publication Date

2006

Volume

60

Issue

6

Start / End Page

663 / 671

Related Subject Headings

  • Spectrum Analysis, Raman
  • Refractometry
  • Lipid Bilayers
  • Ethanol
  • Equipment Failure Analysis
  • Equipment Design
  • Combinatorial Chemistry Techniques
  • Analytical Chemistry
  • Algorithms
  • 0913 Mechanical Engineering
 

Citation

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McCain, S. T., Gehm, M. E., Wang, Y., Pitsianis, N. P., & Brady, D. J. (2006). Coded aperture Raman spectroscopy for quantitative measurements of ethanol in a tissue phantom. Applied Spectroscopy, 60(6), 663–671. https://doi.org/10.1366/000370206777670693
McCain, S. T., M. E. Gehm, Y. Wang, N. P. Pitsianis, and D. J. Brady. “Coded aperture Raman spectroscopy for quantitative measurements of ethanol in a tissue phantom.” Applied Spectroscopy 60, no. 6 (2006): 663–71. https://doi.org/10.1366/000370206777670693.
McCain ST, Gehm ME, Wang Y, Pitsianis NP, Brady DJ. Coded aperture Raman spectroscopy for quantitative measurements of ethanol in a tissue phantom. Applied Spectroscopy. 2006;60(6):663–71.
McCain, S. T., et al. “Coded aperture Raman spectroscopy for quantitative measurements of ethanol in a tissue phantom.” Applied Spectroscopy, vol. 60, no. 6, 2006, pp. 663–71. Manual, doi:10.1366/000370206777670693.
McCain ST, Gehm ME, Wang Y, Pitsianis NP, Brady DJ. Coded aperture Raman spectroscopy for quantitative measurements of ethanol in a tissue phantom. Applied Spectroscopy. 2006;60(6):663–671.

Published In

Applied Spectroscopy

DOI

Publication Date

2006

Volume

60

Issue

6

Start / End Page

663 / 671

Related Subject Headings

  • Spectrum Analysis, Raman
  • Refractometry
  • Lipid Bilayers
  • Ethanol
  • Equipment Failure Analysis
  • Equipment Design
  • Combinatorial Chemistry Techniques
  • Analytical Chemistry
  • Algorithms
  • 0913 Mechanical Engineering