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Gene-environment interplay and psychopathology: multiple varieties but real effects.

Publication ,  Journal Article
Rutter, M; Moffitt, TE; Caspi, A
Published in: Journal of child psychology and psychiatry, and allied disciplines
March 2006

Gene-environment interplay is a general term that covers several divergent concepts with different meanings and different implications. In this review, we evaluate research evidence on four varieties of gene-environment interplay. First, we consider epigenetic mechanisms by which environmental influences alter the effects of genes. Second, we focus on variations in heritability according to environmental circumstances. Third, we discuss what is known about gene-environment correlations. Finally, we assess concepts and findings on the interaction between specific identified genes and specific measured environmental risks. In order to provide an understanding of what may be involved in gene-environment interplay, we begin our presentation with a brief historical review of prevailing views about the role of genetic and environmental factors in the causation of mental disorders, and we provide a simplified account of some of the key features of how genes 'work'.

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Published In

Journal of child psychology and psychiatry, and allied disciplines

DOI

EISSN

1469-7610

ISSN

0021-9630

Publication Date

March 2006

Volume

47

Issue

3-4

Start / End Page

226 / 261

Related Subject Headings

  • Temperament
  • Social Environment
  • Schizophrenia
  • Phenotype
  • Mental Disorders
  • Humans
  • Histone Acetyltransferases
  • Gene Expression
  • Developmental & Child Psychology
  • DNA Methylation
 

Citation

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Rutter, M., Moffitt, T. E., & Caspi, A. (2006). Gene-environment interplay and psychopathology: multiple varieties but real effects. Journal of Child Psychology and Psychiatry, and Allied Disciplines, 47(3–4), 226–261. https://doi.org/10.1111/j.1469-7610.2005.01557.x
Rutter, Michael, Terrie E. Moffitt, and Avshalom Caspi. “Gene-environment interplay and psychopathology: multiple varieties but real effects.Journal of Child Psychology and Psychiatry, and Allied Disciplines 47, no. 3–4 (March 2006): 226–61. https://doi.org/10.1111/j.1469-7610.2005.01557.x.
Rutter M, Moffitt TE, Caspi A. Gene-environment interplay and psychopathology: multiple varieties but real effects. Journal of child psychology and psychiatry, and allied disciplines. 2006 Mar;47(3–4):226–61.
Rutter, Michael, et al. “Gene-environment interplay and psychopathology: multiple varieties but real effects.Journal of Child Psychology and Psychiatry, and Allied Disciplines, vol. 47, no. 3–4, Mar. 2006, pp. 226–61. Epmc, doi:10.1111/j.1469-7610.2005.01557.x.
Rutter M, Moffitt TE, Caspi A. Gene-environment interplay and psychopathology: multiple varieties but real effects. Journal of child psychology and psychiatry, and allied disciplines. 2006 Mar;47(3–4):226–261.
Journal cover image

Published In

Journal of child psychology and psychiatry, and allied disciplines

DOI

EISSN

1469-7610

ISSN

0021-9630

Publication Date

March 2006

Volume

47

Issue

3-4

Start / End Page

226 / 261

Related Subject Headings

  • Temperament
  • Social Environment
  • Schizophrenia
  • Phenotype
  • Mental Disorders
  • Humans
  • Histone Acetyltransferases
  • Gene Expression
  • Developmental & Child Psychology
  • DNA Methylation