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Sequence and chromosomal location of the I-309 gene. Relationship to genes encoding a family of inflammatory cytokines.

Publication ,  Journal Article
Miller, MD; Wilson, SD; Dorf, ME; Seuanez, HN; O'Brien, SJ; Krangel, MS
Published in: J Immunol
October 15, 1990

We previously reported the isolation and characterization of a cDNA clone, I-309, that encodes a small secreted protein produced by activated human T lymphocytes. This protein is structurally related to a large number of recently identified proteins that are secreted upon cellular activation. In this report we describe the isolation and characterization of the gene encoding I-309. The genomic organization is essentially identical to that found in the genes encoding the structurally similar proteins TCA-3, hJE/MCP-1, and mJE, strengthening the hypothesis that these genes are evolutionarily related. The region of the I-309 gene 5' of the mRNA cap site exhibits extensive nucleotide sequence homology with the same region of the murine gene TCA-3, providing additional evidence that I-309 and TCA-3 are likely to be homologs. Finally, panels of rodent-human somatic cell hybrids were used to map the I-309 gene to human chromosome 17. In conjunction with recent mapping data from other laboratories, this result suggests the presence of a cluster of related genes on this chromosome.

Duke Scholars

Published In

J Immunol

ISSN

0022-1767

Publication Date

October 15, 1990

Volume

145

Issue

8

Start / End Page

2737 / 2744

Location

United States

Related Subject Headings

  • Transcription, Genetic
  • Regulatory Sequences, Nucleic Acid
  • Multigene Family
  • Molecular Sequence Data
  • Immunology
  • Humans
  • Genes
  • Cloning, Molecular
  • Chromosomes, Human, Pair 17
  • Chemotactic Factors
 

Citation

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MLA
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Miller, M. D., Wilson, S. D., Dorf, M. E., Seuanez, H. N., O’Brien, S. J., & Krangel, M. S. (1990). Sequence and chromosomal location of the I-309 gene. Relationship to genes encoding a family of inflammatory cytokines. J Immunol, 145(8), 2737–2744.
Miller, M. D., S. D. Wilson, M. E. Dorf, H. N. Seuanez, S. J. O’Brien, and M. S. Krangel. “Sequence and chromosomal location of the I-309 gene. Relationship to genes encoding a family of inflammatory cytokines.J Immunol 145, no. 8 (October 15, 1990): 2737–44.
Miller MD, Wilson SD, Dorf ME, Seuanez HN, O’Brien SJ, Krangel MS. Sequence and chromosomal location of the I-309 gene. Relationship to genes encoding a family of inflammatory cytokines. J Immunol. 1990 Oct 15;145(8):2737–44.
Miller, M. D., et al. “Sequence and chromosomal location of the I-309 gene. Relationship to genes encoding a family of inflammatory cytokines.J Immunol, vol. 145, no. 8, Oct. 1990, pp. 2737–44.
Miller MD, Wilson SD, Dorf ME, Seuanez HN, O’Brien SJ, Krangel MS. Sequence and chromosomal location of the I-309 gene. Relationship to genes encoding a family of inflammatory cytokines. J Immunol. 1990 Oct 15;145(8):2737–2744.

Published In

J Immunol

ISSN

0022-1767

Publication Date

October 15, 1990

Volume

145

Issue

8

Start / End Page

2737 / 2744

Location

United States

Related Subject Headings

  • Transcription, Genetic
  • Regulatory Sequences, Nucleic Acid
  • Multigene Family
  • Molecular Sequence Data
  • Immunology
  • Humans
  • Genes
  • Cloning, Molecular
  • Chromosomes, Human, Pair 17
  • Chemotactic Factors