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Life after the screen: making sense of many P-values.

Publication ,  Journal Article
Schmidt, S; Shao, Y; Hauser, ER; Slifer, SH; Martin, ER; Scott, WK; Speer, MC; Pericak-Vance, MA
Published in: Genet Epidemiol
2001

A multiple analytic approach may be useful for analyzing complex traits since different methods extract both similar and distinct, but complementary pieces of information from genome screen data on extended pedigrees. We examined the usefulness of combining p-values both across methods and across adjacent markers, taking into account the observed correlation structure among these p-values. To this end, we employed the recently proposed truncated product method [Zaykin et al., Genet Epidemiol, in press]. It appears that this approach is helpful for visualizing priority regions for follow-up analysis and reducing the number of false-positive linkage signals.

Duke Scholars

Published In

Genet Epidemiol

DOI

ISSN

0741-0395

Publication Date

2001

Volume

21 Suppl 1

Start / End Page

S546 / S551

Location

United States

Related Subject Headings

  • Software
  • Phenotype
  • Models, Genetic
  • Mathematical Computing
  • Humans
  • Genotype
  • Genetic Testing
  • Genetic Predisposition to Disease
  • Epidemiology
  • Chromosome Mapping
 

Citation

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MLA
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Schmidt, S., Shao, Y., Hauser, E. R., Slifer, S. H., Martin, E. R., Scott, W. K., … Pericak-Vance, M. A. (2001). Life after the screen: making sense of many P-values. Genet Epidemiol, 21 Suppl 1, S546–S551. https://doi.org/10.1002/gepi.2001.21.s1.s546
Schmidt, S., Y. Shao, E. R. Hauser, S. H. Slifer, E. R. Martin, W. K. Scott, M. C. Speer, and M. A. Pericak-Vance. “Life after the screen: making sense of many P-values.Genet Epidemiol 21 Suppl 1 (2001): S546–51. https://doi.org/10.1002/gepi.2001.21.s1.s546.
Schmidt S, Shao Y, Hauser ER, Slifer SH, Martin ER, Scott WK, et al. Life after the screen: making sense of many P-values. Genet Epidemiol. 2001;21 Suppl 1:S546–51.
Schmidt, S., et al. “Life after the screen: making sense of many P-values.Genet Epidemiol, vol. 21 Suppl 1, 2001, pp. S546–51. Pubmed, doi:10.1002/gepi.2001.21.s1.s546.
Schmidt S, Shao Y, Hauser ER, Slifer SH, Martin ER, Scott WK, Speer MC, Pericak-Vance MA. Life after the screen: making sense of many P-values. Genet Epidemiol. 2001;21 Suppl 1:S546–S551.
Journal cover image

Published In

Genet Epidemiol

DOI

ISSN

0741-0395

Publication Date

2001

Volume

21 Suppl 1

Start / End Page

S546 / S551

Location

United States

Related Subject Headings

  • Software
  • Phenotype
  • Models, Genetic
  • Mathematical Computing
  • Humans
  • Genotype
  • Genetic Testing
  • Genetic Predisposition to Disease
  • Epidemiology
  • Chromosome Mapping