Potential for expanded power in linkage studies using the ALLEGRO and MERLIN software programs.
Publication
, Journal Article
Rampersaud, E; Scott, WK; Hauser, ER; Speer, MC
Published in: J Med Genet
December 2005
Multipoint linkage analysis in complex diseases requires the use of fast algorithms that can handle many markers and a large number of moderately sized pedigrees with unknown mode of inheritance. This need has led to the development of several competitive software programs. We recently completed a genomic screen of neural tube defects using GENEHUNTER-PLUS and the more recent ALLEGRO. The ALLEGRO software was found to offer expanded power for linkage studies, particularly for childhood onset diseases like neural tube defects, though the results must be treated with caution.
Duke Scholars
Published In
J Med Genet
DOI
EISSN
1468-6244
Publication Date
December 2005
Volume
42
Issue
12
Start / End Page
e68
Location
England
Related Subject Headings
- Software
- Pedigree
- Neural Tube Defects
- Male
- Lod Score
- Linkage Disequilibrium
- Humans
- Genotype
- Genetics & Heredity
- Genetic Linkage
Citation
APA
Chicago
ICMJE
MLA
NLM
Rampersaud, E., Scott, W. K., Hauser, E. R., & Speer, M. C. (2005). Potential for expanded power in linkage studies using the ALLEGRO and MERLIN software programs. J Med Genet, 42(12), e68. https://doi.org/10.1136/jmg.2005.032029
Rampersaud, E., W. K. Scott, E. R. Hauser, and M. C. Speer. “Potential for expanded power in linkage studies using the ALLEGRO and MERLIN software programs.” J Med Genet 42, no. 12 (December 2005): e68. https://doi.org/10.1136/jmg.2005.032029.
Rampersaud E, Scott WK, Hauser ER, Speer MC. Potential for expanded power in linkage studies using the ALLEGRO and MERLIN software programs. J Med Genet. 2005 Dec;42(12):e68.
Rampersaud, E., et al. “Potential for expanded power in linkage studies using the ALLEGRO and MERLIN software programs.” J Med Genet, vol. 42, no. 12, Dec. 2005, p. e68. Pubmed, doi:10.1136/jmg.2005.032029.
Rampersaud E, Scott WK, Hauser ER, Speer MC. Potential for expanded power in linkage studies using the ALLEGRO and MERLIN software programs. J Med Genet. 2005 Dec;42(12):e68.
Published In
J Med Genet
DOI
EISSN
1468-6244
Publication Date
December 2005
Volume
42
Issue
12
Start / End Page
e68
Location
England
Related Subject Headings
- Software
- Pedigree
- Neural Tube Defects
- Male
- Lod Score
- Linkage Disequilibrium
- Humans
- Genotype
- Genetics & Heredity
- Genetic Linkage