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Effect of donor age on survival of liver transplant recipients with hepatitis C virus infection.

Publication ,  Journal Article
Condron, SL; Heneghan, MA; Patel, K; Dev, A; McHutchison, JG; Muir, AJ
Published in: Transplantation
July 15, 2005

BACKGROUND: Chronic hepatitis C virus (HCV) infection is the most common indication for orthotopic liver transplantation (OLT) in the United States. Recent studies from selected centers have suggested that older donor age is associated with worse outcomes after transplantation for HCV. METHODS: We analyzed the United Network for Organ Sharing Liver Transplant Registry database from April 1987 to March 2003 to examine predictors of death or retransplantation in patients with HCV. Univariate models for each predictor were evaluated. Factors significant in the univariate model were used to develop a multivariable model. RESULTS: Of 6,956 patients meeting the inclusion/exclusion criteria, 1,527 (22.0%) died or received retransplants during the first year after transplant. Recipients with graft failure were older, had greater serum creatinine levels, and were more likely to require mechanical ventilation and hemodialysis before transplant. Donors of patients with graft failure were older and more likely to have diabetes mellitus. In the multivariable regression model, predictors of graft failure at 1 year were donor age, recipient age, recipient creatinine greater than 2 mg/dL, and the requirement for mechanical ventilation for the recipient. CONCLUSIONS: Both older donor age and older recipient age plus markers of severity of disease, including requirement for mechanical ventilation and renal insufficiency, are negatively associated with survival after liver transplantation. These factors should be considered when assessing OLT recipient and donor candidacy in patients with HCV.

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Published In

Transplantation

DOI

ISSN

0041-1337

Publication Date

July 15, 2005

Volume

80

Issue

1

Start / End Page

145 / 148

Location

United States

Related Subject Headings

  • Tissue Donors
  • Survival Analysis
  • Surgery
  • Retrospective Studies
  • Patient Selection
  • Middle Aged
  • Male
  • Liver Transplantation
  • Humans
  • Hepatitis C
 

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Condron, S. L., Heneghan, M. A., Patel, K., Dev, A., McHutchison, J. G., & Muir, A. J. (2005). Effect of donor age on survival of liver transplant recipients with hepatitis C virus infection. Transplantation, 80(1), 145–148. https://doi.org/10.1097/01.tp.0000164291.35925.7a
Condron, Steven L., Michael A. Heneghan, Keyur Patel, Anouk Dev, John G. McHutchison, and Andrew J. Muir. “Effect of donor age on survival of liver transplant recipients with hepatitis C virus infection.Transplantation 80, no. 1 (July 15, 2005): 145–48. https://doi.org/10.1097/01.tp.0000164291.35925.7a.
Condron SL, Heneghan MA, Patel K, Dev A, McHutchison JG, Muir AJ. Effect of donor age on survival of liver transplant recipients with hepatitis C virus infection. Transplantation. 2005 Jul 15;80(1):145–8.
Condron, Steven L., et al. “Effect of donor age on survival of liver transplant recipients with hepatitis C virus infection.Transplantation, vol. 80, no. 1, July 2005, pp. 145–48. Pubmed, doi:10.1097/01.tp.0000164291.35925.7a.
Condron SL, Heneghan MA, Patel K, Dev A, McHutchison JG, Muir AJ. Effect of donor age on survival of liver transplant recipients with hepatitis C virus infection. Transplantation. 2005 Jul 15;80(1):145–148.

Published In

Transplantation

DOI

ISSN

0041-1337

Publication Date

July 15, 2005

Volume

80

Issue

1

Start / End Page

145 / 148

Location

United States

Related Subject Headings

  • Tissue Donors
  • Survival Analysis
  • Surgery
  • Retrospective Studies
  • Patient Selection
  • Middle Aged
  • Male
  • Liver Transplantation
  • Humans
  • Hepatitis C