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Topographic relation of cervical ectropion and vaginal adenosis to clear cell adenocarcinoma.

Publication ,  Journal Article
Robboy, SJ; Welch, WR; Young, RH; Truslow, GY; Herbst, AL; Scully, RE
Published in: Obstet Gynecol
November 1982

Twenty specimens of uterus and vagina removed because of clear cell adenocarcinoma of the cervix or vagina in women exposed prenatally to diethylstilbestrol were serially blocked and sectioned to study the topographic relation between the carcinoma and the cervical ectropion and vaginal adenosis. Three tumors were cervical; 17 were vaginal. Iodine staining performed on 8 specimens indicated that the carcinoma developed consistently just above the distal limit of the cervical or vaginal surface that failed to stain with iodine, a location that usually corresponds to the distal limit of abnormality visible by colposcopic examination. Microscopic examination disclosed the presence of both cervical ectropion and vaginal adenosis in all the specimens. Mucinous glands were abundant above the tumor. In 18 of the 20 cases, tuboendometrial glands were intimately related to the carcinoma, either surrounding it or abutting its inferior border. These data, in addition to other evidence, suggest that tuboendometrial epithelium, whether in the ectocervix or vagina, provides the bed from which clear cell adenocarcinoma develops.

Duke Scholars

Published In

Obstet Gynecol

ISSN

0029-7844

Publication Date

November 1982

Volume

60

Issue

5

Start / End Page

546 / 551

Location

United States

Related Subject Headings

  • Vaginal Neoplasms
  • Vaginal Diseases
  • Uterine Cervical Neoplasms
  • Obstetrics & Reproductive Medicine
  • Humans
  • Female
  • Epithelium
  • Ectoderm
  • Diethylstilbestrol
  • Cervix Uteri
 

Citation

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MLA
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Robboy, S. J., Welch, W. R., Young, R. H., Truslow, G. Y., Herbst, A. L., & Scully, R. E. (1982). Topographic relation of cervical ectropion and vaginal adenosis to clear cell adenocarcinoma. Obstet Gynecol, 60(5), 546–551.
Robboy, S. J., W. R. Welch, R. H. Young, G. Y. Truslow, A. L. Herbst, and R. E. Scully. “Topographic relation of cervical ectropion and vaginal adenosis to clear cell adenocarcinoma.Obstet Gynecol 60, no. 5 (November 1982): 546–51.
Robboy SJ, Welch WR, Young RH, Truslow GY, Herbst AL, Scully RE. Topographic relation of cervical ectropion and vaginal adenosis to clear cell adenocarcinoma. Obstet Gynecol. 1982 Nov;60(5):546–51.
Robboy, S. J., et al. “Topographic relation of cervical ectropion and vaginal adenosis to clear cell adenocarcinoma.Obstet Gynecol, vol. 60, no. 5, Nov. 1982, pp. 546–51.
Robboy SJ, Welch WR, Young RH, Truslow GY, Herbst AL, Scully RE. Topographic relation of cervical ectropion and vaginal adenosis to clear cell adenocarcinoma. Obstet Gynecol. 1982 Nov;60(5):546–551.
Journal cover image

Published In

Obstet Gynecol

ISSN

0029-7844

Publication Date

November 1982

Volume

60

Issue

5

Start / End Page

546 / 551

Location

United States

Related Subject Headings

  • Vaginal Neoplasms
  • Vaginal Diseases
  • Uterine Cervical Neoplasms
  • Obstetrics & Reproductive Medicine
  • Humans
  • Female
  • Epithelium
  • Ectoderm
  • Diethylstilbestrol
  • Cervix Uteri