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Histologic, nuclear DNA, and human papillomavirus studies of cervical condylomas.

Publication ,  Journal Article
Fu, YS; Braun, L; Shah, KV; Lawrence, WD; Robboy, SJ
Published in: Cancer
November 1, 1983

Fifty-four cervical condylomatous lesions, with and without nuclear atypia, from 42 women, were studied with the Feulgen microspectrophotometric technique for nuclear DNA quantitation and an immunoperoxidase technique for human papillomavirus (HPV) antigen. All ordinary cervical condylomas (without atypia/dysplasia) had a diploid or polyploid nuclear DNA distribution; 61% had detectable HPV antigen. Among the cervical condylomas with atypia/dysplasia, 55% (17/31) had diploid or polyploid nuclear DNA pattern, and, of these, 59% (10/17) had demonstrable papillomavirus antigen. Fourteen (45%) were aneuploid lesions, 2 of which had a small number of cells with papillomavirus antigen (14%). These findings suggest that the majority of cervical condylomas are related to papillomavirus infection. That lesions with dysplasia, including high degrees of dysplasia, may also exhibit coexistence of papillomavirus infection suggests the possibility of an infectious etiology in the genesis of cervical squamous neoplasia.

Duke Scholars

Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

November 1, 1983

Volume

52

Issue

9

Start / End Page

1705 / 1711

Location

United States

Related Subject Headings

  • Uterine Cervical Neoplasms
  • Tumor Virus Infections
  • Staining and Labeling
  • Spectrophotometry
  • Papillomaviridae
  • Oncology & Carcinogenesis
  • Middle Aged
  • Immunoenzyme Techniques
  • Humans
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Fu, Y. S., Braun, L., Shah, K. V., Lawrence, W. D., & Robboy, S. J. (1983). Histologic, nuclear DNA, and human papillomavirus studies of cervical condylomas. Cancer, 52(9), 1705–1711. https://doi.org/10.1002/1097-0142(19831101)52:9<1705::aid-cncr2820520926>3.0.co;2-d
Fu, Y. S., L. Braun, K. V. Shah, W. D. Lawrence, and S. J. Robboy. “Histologic, nuclear DNA, and human papillomavirus studies of cervical condylomas.Cancer 52, no. 9 (November 1, 1983): 1705–11. https://doi.org/10.1002/1097-0142(19831101)52:9<1705::aid-cncr2820520926>3.0.co;2-d.
Fu YS, Braun L, Shah KV, Lawrence WD, Robboy SJ. Histologic, nuclear DNA, and human papillomavirus studies of cervical condylomas. Cancer. 1983 Nov 1;52(9):1705–11.
Fu, Y. S., et al. “Histologic, nuclear DNA, and human papillomavirus studies of cervical condylomas.Cancer, vol. 52, no. 9, Nov. 1983, pp. 1705–11. Pubmed, doi:10.1002/1097-0142(19831101)52:9<1705::aid-cncr2820520926>3.0.co;2-d.
Fu YS, Braun L, Shah KV, Lawrence WD, Robboy SJ. Histologic, nuclear DNA, and human papillomavirus studies of cervical condylomas. Cancer. 1983 Nov 1;52(9):1705–1711.
Journal cover image

Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

November 1, 1983

Volume

52

Issue

9

Start / End Page

1705 / 1711

Location

United States

Related Subject Headings

  • Uterine Cervical Neoplasms
  • Tumor Virus Infections
  • Staining and Labeling
  • Spectrophotometry
  • Papillomaviridae
  • Oncology & Carcinogenesis
  • Middle Aged
  • Immunoenzyme Techniques
  • Humans
  • Female